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Cardiology Research and Practice
Volume 2012, Article ID 240497, 11 pages
http://dx.doi.org/10.1155/2012/240497
Review Article

Myocardial Restoration: Is It the Cell or the Architecture or Both?

1Department of Surgery, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 119228
2National University Health System, Department of Cardiac, Thoracic and Vascular Surgery, 1E Lower Kent Ridge Road, NUHS Tower Block, Level 8, Singapore 119228

Received 2 July 2011; Accepted 28 October 2011

Academic Editor: Marco Metra

Copyright © 2012 Duc Thang Vu and Theo Kofidis. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Myocardial infarction is the leading cause of death in developed countries. Cardiac cell therapy has been introduced to clinical trials for more than ten years but its results are still controversial. Tissue engineering has addressed some limitations of cell therapy and appears to be a promising solution for cardiac regeneration. In this review, we would like to summarize the current understanding about the therapeutic effect of cell therapy and tissue engineering under purview of functional and structural aspects, highlighting actual roles of each therapy towards clinical application.