miRNAs-based therapeutic strategies in vascular repairs, There are two major approaches to developing miRNA-based therapeutics: miRNA antagonists and miRNA mimics. miRNA antagonists are generated to inhibit endogenous miRNAs that show a pathogenic gain-of-function in diseased tissues. miRNA mimics are used to upregulate expression of beneficial miRNAs. Inhibition of miR-92a, miR-100 and miR-503 or increase of miR-210 can promote angiogenesis, thus improving postischemic blood flow recovery in limb ischemia or myocardial infarction.
