Nitric Oxide Manipulation: A Therapeutic Target for Peripheral Arterial Disease?

Table 1

Fontaine Classification: stages III and IV are also known as CLI.

Stage I	Asymptomatic
Stage II	Intermittent claudication, no rest pain
IIa	When walking a distance of greater than 200 m
IIb	When walking a distance of less than 200 m
Stage III	Nocturnal pain and/or pain at rest
Stage IV	Tissue loss: ischaemic ulcers and/or gangrene