Table of Contents Author Guidelines Submit a Manuscript
Cardiology Research and Practice
Volume 2012, Article ID 735829, 5 pages
http://dx.doi.org/10.1155/2012/735829
Review Article

Pathophysiological Implications of Different Bicuspid Aortic Valve Configurations

Department of Cardiovascular Surgery, Heart Center Freiburg University, Hugstetter Straβe 55, 79106 Freiburg, Germany

Received 15 February 2012; Accepted 28 March 2012

Academic Editor: Martin Misfeld

Copyright © 2012 F. A. Kari et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. S. S. Fazel, H. R. Mallidi, R. S. Lee et al., “The aortopathy of bicuspid aortic valve disease has distinctive patterns and usually involves the transverse aortic arch,” Journal of Thoracic and Cardiovascular Surgery, vol. 135, no. 4, pp. 901–907, 2008. View at Publisher · View at Google Scholar · View at Scopus
  2. S. C. Siu and C. K. Silversides, “Bicuspid aortic valve disease,” Journal of the American College of Cardiology, vol. 55, no. 25, pp. 2789–2800, 2010. View at Publisher · View at Google Scholar · View at Scopus
  3. D. Bonderman, E. Gharehbaghi-Schnell, G. Wollenek, G. Maurer, H. Baumgartner, and I. M. Lang, “Mechanisms underlying aortic dilatation in congenital aortic valve malformation,” Circulation, vol. 99, no. 16, pp. 2138–2143, 1999. View at Google Scholar · View at Scopus
  4. T. M. Tadros, M. D. Klein, and O. M. Shapira, “Ascending aortic dilatation associated with bicuspid aortic valve. Pathophysiology, molecular biology, and clinical implications,” Circulation, vol. 119, no. 6, pp. 880–890, 2009. View at Publisher · View at Google Scholar · View at Scopus
  5. A. Z. Beaton, T. Nguyen, W. W. Lai et al., “Relation of coarctation of the aorta to the occurrence of ascending aortic dilation in children and young adults with bicuspid aortic valves,” American Journal of Cardiology, vol. 103, no. 2, pp. 266–270, 2009. View at Publisher · View at Google Scholar · View at Scopus
  6. H. I. Michelena, A. D. Khanna, D. Mahoney et al., “Incidence of aortic complications in patients with bicuspid aortic valves,” Journal of the American Medical Association, vol. 306, no. 10, pp. 1104–1112, 2011. View at Google Scholar
  7. H. Y. Sabet, W. D. Edwards, H. D. Tazelaar, and R. C. Daly, “Congenitally bicuspid aortic valves: a surgical pathology study of 542 cases (1991 through 1996) and a literature review of 2,715 additional cases,” Mayo Clinic Proceedings, vol. 74, no. 1, pp. 14–26, 1999. View at Google Scholar · View at Scopus
  8. M. G. Keane, S. E. Wiegers, T. Plappert, A. Pochettino, J. E. Bavaria, and M. G. Sutton, “Bicuspid aortic valves are associated with aortic dilatation out of proportion to coexistent valvular lesions,” Circulation, vol. 102, supplement 3, no. 19, pp. III35–III39, 2000. View at Google Scholar · View at Scopus
  9. H. H. Sievers and H. L. Sievers, “Aortopathy in bicuspid aortic valve disease—genes or hemodynamics? or Scylla and Charybdis?” European Journal of Cardio-thoracic Surgery, vol. 39, no. 6, pp. 803–804, 2011. View at Publisher · View at Google Scholar · View at Scopus
  10. H. H. Sievers and C. A. Schmidtke, “A classification system for the bicuspid aortic valve from 304 surgical specimens,” Journal of Thoracic and Cardiovascular Surgery, vol. 133, no. 5, pp. 1226–1233, 2007. View at Publisher · View at Google Scholar · View at Scopus
  11. D. Aicher, T. Kunihara, O. Abou Issa, B. Brittner, S. Gräber, and H. J. Schäfers, “Valve configuration determines long-term results after repair of the bicuspid aortic valve,” Circulation, vol. 123, no. 2, pp. 178–185, 2011. View at Publisher · View at Google Scholar · View at Scopus
  12. J. S. Ikonomidis, J. M. Ruddy, S. M. Benton Jr. et al., “Aortic dilatation with bicuspid aortic valves: cusp fusion correlates to matrix metalloproteinases and inhibitors,” Annals of the Royal College of Surgeons of England, vol. 93, no. 2, pp. 457–463, 2011. View at Google Scholar
  13. P. M. den Reijer, D. Sallee 3rd, P. van der Velden et al., “Hemodynamic predictors of aortic dilatation in bicuspid aortic valve by velocity-encoded cardiovascular magnetic resonance,” Journal of Cardiovascular Magnetic Resonance, vol. 12, no. 1, p. 4, 2010. View at Publisher · View at Google Scholar · View at Scopus
  14. C. F. Russo, A. Cannata, M. Lanfranconi, E. Vitali, A. Garatti, and E. Bonacina, “Is aortic wall degeneration related to bicuspid aortic valve anatomy in patients with valvular disease?” Journal of Thoracic and Cardiovascular Surgery, vol. 136, no. 4, pp. 937–942, 2008. View at Publisher · View at Google Scholar · View at Scopus
  15. W. C. Roberts, T. J. Vowels, J. M. Ko et al., “Comparison of the structure of the aortic valve and ascending aorta in adults having aortic valve replacement for aortic stenosis versus for pure aortic regurgitation and resection of the ascending aorta for aneurysm,” Circulation, vol. 123, no. 8, pp. 896–903, 2011. View at Publisher · View at Google Scholar · View at Scopus
  16. B. Lima, J. B. Williams, S. D. Bhattacharya et al., “Individualized thoracic aortic replacement for the aortopathy of biscuspid aortic valve disease,” Journal of Heart Valve Disease, vol. 20, no. 4, pp. 387–395, 2011. View at Google Scholar
  17. V. Jackson, J. Petrini, K. Caidahl et al., “Bicuspid aortic valve leaflet morphology in relation to aortic root morphology: a study of 300 patients undergoing open-heart surgery,” European Journal of Cardio-Thoracic Surgery, vol. 40, no. 3, pp. e118–e124, 2011. View at Publisher · View at Google Scholar · View at Scopus
  18. D. Aicher, F. Langer, A. Kissinger, H. Lausberg, R. Fries, and H. J. Schäfers, “Valve-sparing aortic root replacement in bicuspid aortic valves: a reasonable option?” Journal of Thoracic and Cardiovascular Surgery, vol. 128, no. 5, pp. 662–668, 2004. View at Publisher · View at Google Scholar · View at Scopus
  19. B. L. Kroner, H. E. Tolunay, C. T. Basson et al., “The national registry of genetically triggered thoracic aortic aneurysms and cardiovascular conditions (GenTAC): results from phase I and scientific opportunities in phase II,” American Heart Journal, vol. 162, no. 4, pp. 627–632, 2011. View at Google Scholar
  20. S. Biner, A. M. Rafique, I. Ray, O. Cuk, R. J. Siegel, and K. Tolstrup, “Aortopathy is prevalent in relatives of bicuspid aortic valve patients,” Journal of the American College of Cardiology, vol. 53, no. 24, pp. 2288–2295, 2009. View at Google Scholar · View at Scopus
  21. H. Yasuda, S. Nakatani, M. Stugaard et al., “Failure to prevent progressive dilation of ascending aorta by aortic valve replacement in patients with bicuspid aortic valve: comparison with tricuspid aortic valve,” Circulation, vol. 108, supplement 1, no. 10, pp. II291–II294, 2003. View at Google Scholar · View at Scopus
  22. L. J. Martin, R. B. Hinton, X. Zhang, L. H. Cripe, and D. W. Benson, “Aorta measurements are heritable and influenced by bicuspid aortic valve,” Frontiers in Genetics, vol. 2, article 61, 2011. View at Google Scholar
  23. S. Kurtovic, V. Paloschi, L. Folkersen, J. Gottfries, A. Franco-Cereceda, and P. Eriksson, “Diverging alternative splicing fingerprints in the transforming growth factor-β signaling pathway identified in thoracic aortic aneurysms,” Molecular Medicine, vol. 17, no. 7-8, pp. 665–675, 2011. View at Publisher · View at Google Scholar · View at Scopus
  24. D. Gomez, A. Coyet, V. Ollivier et al., “Epigenetic control of vascular smooth muscle cells in Marfan and non-Marfan thoracic aortic aneurysms,” Cardiovascular Research, vol. 89, no. 2, pp. 446–456, 2011. View at Publisher · View at Google Scholar · View at Scopus
  25. E. C. Wooten, L. K. Iyer, M. C. Montefusco et al., “Application of gene network analysis techniques identifies AXIN1/PDIA2 and endoglin haplotypes associated with bicuspid aortic valve,” PloS ONE, vol. 5, no. 1, p. e8830, 2010. View at Publisher · View at Google Scholar · View at Scopus
  26. V. Paloschi, S. Kurtovic, L. Folkersen et al., “Impaired splicing of fibronectin is associated with thoracic aortic aneurysm formation in patients with bicuspid aortic valve,” Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 31, no. 3, pp. 691–697, 2011. View at Publisher · View at Google Scholar · View at Scopus
  27. I. Foffa, M. Murzi, and M. Mariani, “Angiotensin-converting enzyme insertion/deletion polymorphism is a risk factor for thoracic aortic aneurysm in patients with bicuspid or tricuspid aortic valves,” The Journal of Thoracic and Cardiovascular Surgery. In press.
  28. G. M. Raffa, V. Jackson, J. Liska et al., “Endothelin-1 and brain natriuretic peptide plasma levels decrease after aortic surgery,” Journal of Heart Valve Disease, vol. 19, no. 6, pp. 724–730, 2010. View at Google Scholar · View at Scopus
  29. M. Vaturi, L. Perl, D. Leshem-Lev et al., “Circulating endothelial progenitor cells in patients with dysfunctional versus normally functioning congenitally bicuspid aortic valves,” American Journal of Cardiology, vol. 108, no. 2, pp. 272–276, 2011. View at Publisher · View at Google Scholar · View at Scopus
  30. L. Folkersen, D. Wagsater, V. Paloschi et al., “Unraveling divergent gene expression profiles in bicuspid and tricuspid aortic valve patients with thoracic aortic dilatation: the ASAP study,” Molecular Medicine, vol. 17, no. 11-12, pp. 1365–1373, 2011. View at Publisher · View at Google Scholar