Review Article
Pathophysiological Implications of Different Bicuspid Aortic Valve Configurations
Table 2
Hereditary factors—longitudinal extent—arch involvement of aortopathy.
| Aortic dilation patterns are distributed similarly regardless of BAV type [1, 17] | | BAV patients’ relatives with tricuspid aortic valve have stiffer, less compliant, and somewhat enlarged aortas [20] | | After isolated BAV replacement, aortic dilation progresses and the risk of aortic rupture and dissection remain higher [21] | | Aortic diameter per se is a quantitative trait that exhibits significant familial heritability—bicuspid aortic valve is independent modifier [22] | | TGF-beta signaling—differential splicing is specific for BAV and TAV patients [23] | | Defective fibronectin splicing within the aortic wall of bicuspid aortic valve is associated with aortic aneurysm development [26] | | ACE insertion/deletion polymorphism associated with aneurysm formation [27] | |
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