Cardiology Research and Practice / 2012 / Article / Tab 1

Review Article

The Diabetic Heart: Too Sweet for Its Own Good?

Table 1

Studies indicating the diabetic heart is more sensitive to ischemic injury compared to normoglycemic controls.

StudyModelIschemic protocolDuration/onset of diabetesSubstrates Model of diabetesEnd points

Jones et al. (1999) [26]db/db mouseIn vivo non recovery, 30 min regional ischemia/2 h reperfusionIn-bred strainIn vivo substratesType II diabetesInfarction

Kersten et al. (2000) [27]Dog, Alloxan (40 mg/kg) and STZ (25 mg/kg)In vivo non recovery, 60 min regional ischemia/3 h reperfusion3 weeksIn vivo substratesType I diabetesInfarction

Kersten et al. (2000) [27]Dog, Dextrose 15% to cause acute hyperglycaemiaIn vivo non recovery, 60 min regional ischemia/3 h reperfusion70 minsIn vivo substratesType I diabetesInfarction

Lefer et al. (2001) [28]db/db mouseIn vivo non recovery, 30 min regional ischemia/2 h reperfusionIn-bred strainIn vivo substratesType II diabetesInfarction

Fiordaliso et al. (2001) [29]Rat cardiomyocytes1, 2, and 4 days of 25 mmol/L incubation in mediumType I diabetesCell death

Marfella et al. (2002) [30]Sprague-Dawley Rat, STZ (70 mg/kg i.v)In vivo non recovery, 25 min regional ischemia/2 h reperfusion9 daysIn vivo substratesType I diabetesInfarction and protein expression

Marfella et al. (2002) [30]Sprague-Dawley Rat, isolated heartLangendorff isolated heart, 25 min regional ischemia/2 hr reperfusion33.3 mmol/L glucoseType I diabetesInfarction and protein expression

Ebel et al. (2003) [31]Rabbit- 50% Dextrose infused 30 min prior to ischemia until reperfusion normoglycaemic rat-under intravenousIn vivo non recovery, 30 min regional ischemia/2 h reperfusionhyperglycemia of 600 mgd1-1 throughout ischemiaIn vivo substratesType I diabetesInfarction
Su et al. (2007) [32]infusion at a rate of 4 mL·kg–1·h–1: of glucose 500 g/l during ischemia, saline during reperfusionIn vivo non recovery, 30 min regional ischemia/6 h reperfusionIn vivo substratesType I diabetesInfarction, apoptosis and kinase expression

Desrois et al. (2010) [33]Aging Goto Kakizaki Rat, maleLangendorff isolated heart, 32 min low flow global ischemia/32 min reperfusionIn-bred strain1.2 mM palmitate, 3% albumin, 11 mM glucose, 3 U/l insulin, 0.8 mM lactate, and 0.2 mM pyruvate.Type II diabetesMyocardial function

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