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Cardiology Research and Practice
Volume 2012, Article ID 925046, 10 pages
Clinical Study

Hypertension Control and Cardiometabolic Risk: A Regional Perspective

1Institute for Clinical Pharmacology, Medical Faculty Carl Gustav Carus, Technical University Dresden, 01307 Dresden, Germany
2Léman Research Institute GmbH, 6300 Zug, Switzerland
3Institute for Cardiovascular Pharmacology and Epidemiology, 15831 Mahlow, Germany
4Medical Affairs Department, Sanofi, Shanghai 200000, China
5Cardiology Division and Hypertension Unit, S. Andrea Hospital, La Sapienza University of Rome, 00189 Rome, Italy
6I. R. C. C. S. Neuromed, 86077 Pozzili, Italy
7Medical Affairs Department, Sanofi-Aventis (Suisse) SA, 1217 Meyrin, Switzerland

Received 11 August 2011; Accepted 1 November 2011

Academic Editor: Bobby Varkey Khan

Copyright © 2012 Martin Thoenes et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Background. We investigated the association between blood pressure control and common cardiometabolic risk factors from a global and regional perspective. Methods. In the present analysis of a large cross-sectional i-SEARCH study, 17.092 outpatients receiving antihypertensive treatment were included in 26 countries. According to clinical guidelines for the management of arterial hypertension, patients were classified based on the level of seated systolic/diastolic blood pressure (SBP/DBP). Uncontrolled hypertension was defined as SBP/DBP ≥140/90 mmHg for non-diabetics, and ≥130/80 mmHg for diabetics. Results. Overall, mean age was 63.1 years, 52.8% were male, and mean BMI was 28.9 kg/m2. Mean SBP/DBP was 148.9/87.0 mmHg, and 76.3% of patients had uncontrolled hypertension. Diabetes was present in 29.1% with mean HbA1c of 6.8%. Mean LDL-cholesterol was 3.2 mmol/L, HDL-cholesterol 1.3 mmol/L, and triglycerides 1.8 mmol/L; 49.0% had hyperlipidemia. Patients with uncontrolled hypertension had a higher BMI (29.4 versus 28.6 kg/m2), LDL-cholesterol (3.4 versus 3.0 mmol/L), triglycerides (1.9 versus 1.7 mmol/L), and HbA1c (6.8 versus 6.7%) than those with controlled blood pressure ( for all parameters). Conclusions. Among outpatients treated for arterial hypertension, three quarters had uncontrolled blood pressure. Elevated SBP/DBP and uncontrolled hypertension were associated with increasing BMI, LDL-cholesterol, triglycerides, and HbA1c, both globally and regionally.