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Cardiology Research and Practice
Volume 2014 (2014), Article ID 945951, 7 pages
http://dx.doi.org/10.1155/2014/945951
Clinical Study

Central Arterial Hemodynamic Effects of Dark Chocolate Ingestion in Young Healthy People: A Randomized and Controlled Trial

1Departamento de Cardiopneumologia, ESTESC, Instituto Politécnico de Coimbra, Rua 5 de Outubro, SM Bispo, Apartado 7006, 3046-854 Coimbra, Portugal
2Instituto de Investigacao e Formacao Cardiovascular, Quinta da Portela, Rua Princesa Cindazunda, Lote 9.3, Loja 94, 3030-503 Coimbra, Portugal

Received 27 February 2014; Revised 7 May 2014; Accepted 8 May 2014; Published 27 May 2014

Academic Editor: Frans Leenen

Copyright © 2014 T. Pereira et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. A. J. Flammer, F. Hermann, I. Sudano et al., “Dark chocolate improves coronary vasomotion and reduces platelet reactivity,” Circulation, vol. 116, no. 21, pp. 2376–2382, 2007. View at Publisher · View at Google Scholar · View at Scopus
  2. M. E. Widlansky, N. Gokce, J. F. Keaney Jr., and J. A. Vita, “The clinical implications of endothelial dysfunction,” Journal of the American College of Cardiology, vol. 42, no. 7, pp. 1149–1160, 2003. View at Publisher · View at Google Scholar · View at Scopus
  3. K. J. Murphy, A. K. Chronopoulos, I. Singh et al., “Dietary flavanols and procyanidin oligomers from cocoa (Theobroma cacao) inhibit platelet function,” The American Journal of Clinical Nutrition, vol. 77, no. 6, pp. 1466–1473, 2003. View at Google Scholar · View at Scopus
  4. C. L. Keen, R. R. Holt, P. I. Oteiza, C. G. Fraga, and H. H. Schmitz, “Cocoa antioxidants and cardiovascular health,” The American Journal of Clinical Nutrition, vol. 81, supplement 1, pp. S298–S303, 2005. View at Google Scholar · View at Scopus
  5. C. Vlachopoulos, K. Aznaouridis, N. Alexopoulos, E. Economou, I. Andreadou, and C. Stefanadis, “Effect of dark chocolate on arterial function in healthy individuals,” The American Journal of Hypertension, vol. 18, no. 6, pp. 785–791, 2005. View at Publisher · View at Google Scholar · View at Scopus
  6. M. B. Engler, M. M. Engler, C. Y. Chen et al., “Flavonoid-rich dark chocolate improves endothelial function and increases plasma epicatechin concentrations in healthy adults,” Journal of the American College of Nutrition, vol. 23, no. 3, pp. 197–204, 2004. View at Google Scholar · View at Scopus
  7. Z. Faridi, V. Y. Njike, S. Dutta, A. Ali, and D. L. Katz, “Acute dark chocolate and cocoa ingestion and endothelial function: a randomized controlled crossover trial,” The American Journal of Clinical Nutrition, vol. 88, no. 1, pp. 58–63, 2008. View at Google Scholar · View at Scopus
  8. H. M. O. Farouque, M. Leung, S. A. Hope et al., “Acute and chronic effects of flavanol-rich cocoa on vascular function in subjects with coronary artery disease: a randomized double-blind placebo-controlled study,” Clinical Science, vol. 111, no. 1, pp. 71–80, 2006. View at Publisher · View at Google Scholar · View at Scopus
  9. J. M. Hodgson and K. D. Croft, “Dietary flavonoids: effects on endothelial function and blood pressure,” Journal of the Science of Food and Agriculture, vol. 86, no. 15, pp. 2492–2498, 2006. View at Publisher · View at Google Scholar · View at Scopus
  10. S. Mathur, S. Devaraj, S. M. Grundy, and I. Jialal, “Cocoa products decrease low density lipoprotein oxidative susceptibility but do not affect biomarkers of inflammation in humans,” Journal of Nutrition, vol. 132, no. 12, pp. 3663–3667, 2002. View at Google Scholar · View at Scopus
  11. C. V. Vlachopoulos, N. A. Alexopoulos, K. A. Aznaouridis et al., “Relation of habitual cocoa consumption to aortic stiffness and wave reflections, and to central hemodynamics in healthy individuals,” The American Journal of Cardiology, vol. 99, no. 10, pp. 1473–1475, 2007. View at Publisher · View at Google Scholar · View at Scopus
  12. Y. Wan, J. A. Vinson, T. D. Etherton, J. Proch, S. A. Lazarus, and P. M. Kris-Etherton, “Effects of cocoa powder and dark chocolate on LDL oxidative susceptibility and prostaglandin concentrations in humans,” The American Journal of Clinical Nutrition, vol. 74, no. 5, pp. 596–602, 2001. View at Google Scholar · View at Scopus
  13. J. F. Wang-Polagruto, A. C. Villablanca, J. A. Polagruto et al., “Chronic consumption of flavanol-rich cocoa improves endothelial function and decreases vascular cell adhesion molecule in hypercholesterolemic postmenopausal women,” Journal of Cardiovascular Pharmacology, vol. 47, supplement 2, pp. S177–S186, 2006. View at Publisher · View at Google Scholar · View at Scopus
  14. J. Calabia, P. Torguet, M. Garcia et al., “Doppler ultrasound in the measurement of pulse wave velocity: agreement with the Complior method,” Cardiovascular Ultrasound, vol. 9, no. 1, article 13, 2011. View at Publisher · View at Google Scholar · View at Scopus
  15. T. Pereira and J. Maldonado, “Performance of the Colson MAM BP 3AA1-2 automatic blood pressure monitor according to the European Society of Hypertension validation protocol,” Revista Portuguesa de Cardiologia, vol. 24, no. 11, pp. 1341–1351, 2005. View at Google Scholar · View at Scopus
  16. K. Sutton-Tyrrell, S. S. Najjar, R. M. Boudreau et al., “Elevated aortic pulse wave velocity, a marker of arterial stiffness, predicts cardiovascular events in well-functioning older adults,” Circulation, vol. 111, no. 25, pp. 3384–3390, 2005. View at Publisher · View at Google Scholar · View at Scopus
  17. L. G. Mészáros and J. Mihalicza, “Flow-mediated vasodilation pulse by pulse,” Artery Research, vol. 6, pp. 173–174, 2012. View at Google Scholar
  18. J. Martins and S. Carlota, “Endotélio arterial e aterotrombogénese II—disfunção endotelial e desenvolvimento,” Revista Portuguesa de Cardiologia, vol. 25, no. 12, pp. 1159–1186, 2006. View at Google Scholar
  19. O. Pizzi and A. Brandão, “Velocidade de onda de pulso-o método e suas implicações prognosticas na hipertensão arterial,” Revista Brasileira de Hipertensão, vol. 13, no. 1, pp. 59–62, 2006. View at Google Scholar
  20. T. T. de Oliveira, R. R. da Silva, W. C. A. Dornas, and T. J. Nagem, “Flavonóides e aterosclerose,” Biologia, vol. 42, no. 1, pp. 49–54, 2010. View at Google Scholar
  21. J. Balzer, T. Rassaf, C. Heiss et al., “Sustained benefits in vascular function through flavanol-containing cocoa in medicated diabetic patients. A double-masked, randomized, controlled trial,” Journal of the American College of Cardiology, vol. 51, no. 22, pp. 2141–2149, 2008. View at Publisher · View at Google Scholar · View at Scopus