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Cardiology Research and Practice
Volume 2015, Article ID 104818, 5 pages
Clinical Study

Myocardial Injury in Children with Unoperated Congenital Heart Diseases

1Pediatrics Department, Faculty of Medicine, Zagazig University, Zagazig 44519, Egypt
2Cardiology Department, Faculty of Medicine, Zagazig University, Zagazig 44519, Egypt

Received 13 October 2015; Revised 30 October 2015; Accepted 2 November 2015

Academic Editor: Mariantonietta Cicoira

Copyright © 2015 Mohamed O. Hafez et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Background. Children with congenital heart diseases (CHDs) may have a risk of developing myocardial injury caused by volume and pressure overload. Objective. To evaluate the incidence of myocardial injury in children with cyanotic and acyanotic CHDs using cTnI assay and to correlate it with different hemodynamic parameters. Methods. This study included 80 children with CHDs (40 acyanotic and 40 cyanotic) as well as 40 healthy children (control group). Serum cTnI levels were measured for patients and control. Pulmonary to systemic blood flow (Qp/Qs) and pulmonary to systemic arterial pressure (Pp/Ps) ratios were measured for children with CHDs during cardiac catheterization. Results. Sixty-four out of 80 patients with CHDs had myocardial injury as evidenced by increased cTnI. Serum cTnI was significantly higher in both cyanotic and acyanotic groups compared to control group (). Serum cTnI level significantly correlated with oxygen saturation (SpO2), ejection fraction (EF), Qp/Qs, and Pp/Ps ratios. Conclusion. The incidence of myocardial injury was high in children with CHDs. The use of cTnI for follow-up of children with CHDs may help early detection of myocardial injury and help early management of these cases.