Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes Afford New Opportunities in Inherited Cardiovascular Disease Modeling

Table 4

Human IPSC-derived patient-specific CPVT syndrome cell models.

Gene	Protein	Mutation	Donor cell types	Reprogramming method	References
CASQ2	Calsequestrin 2	p.D307H	Fibroblasts	LV, OSKM	[39]
RyR2	Ryanodine receptor 2	p.P2328S	Fibroblasts	RV, OSKM	[47]
RyR2	Ryanodine receptor 2	p.F2483I	Fibroblasts	RV, OSKM	[45]
RyR2	Ryanodine receptor 2	p.S406L	Fibroblasts	RV, OSKM	[46]

LV: lentiviruses, RV: retroviruses, and OCT4 (O), SOX2 (S), KLF4 (K), and c-MYC (M).