Assessment of the Protective Role of Prenatal Zinc versus Insulin Supplementation on Fetal Cardiac Damage Induced by Maternal Diabetes in Rat Using Caspase-3 and KI67 Immunohistochemical Stains

Table 5

Percentage frequency distribution of apoptotic index (AI) in caspase-3 immunohistochemical stained myocardial sections in the different groups.

Parameter	Group
	C	STZ-DM	STZ-DM + Zn	STZ-DM + In
Grade I AI < 1%	88	0	8	5
Grade II AI < 5%	10	2	72	25
Grade III AI: 5–10%	2	23	15	55
Grade IV AI > 10%	0	75	5	15
Total (%)	100	100	100	100

Chi-square 533.86.
value < 0.00001.
C: control group, STZ-DM: streptozotocin-induced diabetic group, STZ-DM + In: streptozotocin-induced diabetic treated with insulin group, and STZ-DM + Zn: streptozotocin-induced diabetic treated with Zn group.
, compared to the control group, compared to the STZ-DM group, and compared to the STZ-DM + Zn group.