Review Article

Dietary Pattern and Macronutrients Profile on the Variation of Inflammatory Biomarkers: Scientific Update

Table 2

Studies that assessed the effect of dietary patterns on the chronic subclinical inflammation.

ReferenceStudy typePopulationMethodsResults

Ozawa et al. [15]Cohort5083 British overweight adult individualsValidated FFQ; determination of factorial inflammatory loadings for food groups and identified two dietary patterns (pro- or anti-inflammatory)Dietary pattern considered inflammatory characterized by red meat, fried foods, and lower ingestion of whole grains: ↑ IL-6

Kuczmarski et al. [40]Cohort2176 American adult individuals24 h recalls; identification of the most consumed foods was grouped according to the similarity of their components and new dietary patterns were created; cluster analysis for definition of ten groupsAll patterns displayed elevated (>3 mg/L) CRP, whereas the highest average was that of the “frozen food” pattern (7.2 ± 1.4 mg/L)

Corley et al. [13]Cross-sectional (from a cohort)792 Scottish elderly eutrophic individualsSelf-applied FFQ; dietary patterns as Mediterranean and conscious (high intake of fruits and carrots and low intake of embedded foods, eggs, pork, and liqueurs)Highest score of the conscious dietary pattern and higher ingestion of fruits: ↓ CRP; highest score of the Mediterranean dietary pattern: ↓ fibrinogen

Kong et al. [5]Case-control45 overweight and obese adults7-day (for overweight and/obese) and 3-day dietary record (for the control group); three dietary patterns were determined: Group 1 (less healthy, high consumption of beverages and foods high in sugar, fat, and salt); Group 2 (healthier, with higher consumption of water, yogurt, cereals, eggs, and nuts); Group 3 (healthier, with a fiber-rich diet, lower consumption of sugar, fruits, yogurt, and soups)Group 3: ↓ sDC14, followed by Group 2 and Group 1; Group 3: ↑ DC163; no differences between the groups for the LPS, CRP, and IL-6 concentrations; higher consumption of fruits, green vegetables, and soups ↑ DC163

Lee et al. [32]Cross-sectional7574 eutrophic adult individualsFFQ; 4 dietary patterns determined as standard: fruit, vegetable, meat, and coffee, according to the prevailing foodHighest score for the “vegetable” pattern: ↓ CRP; highest score for the “vegetable” pattern: ↑ ingestion of antioxidants

Bédard et al. [12]Clinical trial70 Canadian, overweight, adult individuals, with risk of cardiovascular diseaseFour weeks following the Mediterranean patternMale individuals who displayed CRP values > 3 mg/L displayed a reduction over time; male individuals who displayed reduced CRP values (<3 mg/L), displayed an increase over time; no beneficial effect of the Mediterranean diet was observed for both genders

Abete et al. [49]Case-control51 healthy individuals and 51 individuals with history of strokeFFQ; 2 dietary patterns determined as “healthy” and “not healthy”Healthy individuals displayed greater adherence to the healthy dietary pattern, as well as ↓ CRP and ↓ leukocytes

McGeoghegan et al. [44]Cohort1531 healthy and diabetic individuals4-day dietary record during 4 years; 2 dietary patterns determined: “1”—higher antioxidant and anti-inflammatory loads; “2”—lower antioxidant and anti-inflammatory loadsDietary pattern “1” was inversely related to the CRP concentrations

FFQ: Food Frequency Questionnaire; IL-6: interleukin 6; CRP: C-reactive protein; sDC14: differentiation cluster 14; DC163: differentiation cluster 163; LPS: lipopolysaccharide.