Table 2: Study characteristics.

StudyCountrySample sizeMean age (SD)Intervention (sample size)ComparisonMean follow-up timeOutcomes assessed

Pérez-Castellano et al. [13]Spain50CB = 58 (45, 62)
IRF = 56 (40, 61)
Irrigated radiofrequency energy ()Cryoballoon ()12 months(i) Freedom from atrial fibrillation, ablation time, procedure time, fluoroscopy time, complications
Herrera Siklódy et al. [15]France60CB = 57 (8)
IRF = 56 (10)
Irrigated radiofrequency energy ()Cryoballoon ()12 months(i) Freedom from atrial fibrillation, procedure time, fluoroscopy time, complications, biochemical response
Pokushalov et al. [14]Russia80CB = 56 (9)
IRF = 56 (11)
Irrigated radiofrequency energy ()Cryoballoon ()12 months(i) Freedom from atrial fibrillation, procedure time, fluoroscopy time, complications
Hunter et al. [16]United Kingdom234CB = 56 (11)
IRF = 61 (12)
Combined = 58 (12)
Irrigated radiofrequency energy ()
Combined ()
Cryoballoon ()12 months(i) Freedom from atrial fibrillation, procedure time, fluoroscopy time, complications
Schmidt et al. [17]Germany99CB = 66 (10)
IRF = 63 (10)
LB = 65 (8)
Irrigated radiofrequency energy ()
Laser balloon ()
Cryoballoon ()Postoperative(i) Asymptomatic cerebral lesions procedure time
Kuck et al. [6]Germany750CB = 59.9 (9.8)
IRF = 60.1 (9.2)
Irrigated radiofrequency energy ()Cryoballoon ()1.5 years(i) Recurrence of atrial fibrillation, procedure time, fluoroscopy time, complications
Luik et al. [5]Germany215CB = 61 (54, 66)
IRF = 60 (54, 67)
Irrigated radiofrequency energy ()Cryoballoon ()12 months(i) Freedom from atrial fibrillation, complications
Malmborg et al. [18]Sweden110CB = 59 (9)
PDRF = 62 (7)
Phased duty-cycled radiofrequency energy ()Cryoballoon ()12 months(i) Freedom from atrial fibrillation, ablation time, procedure time, fluoroscopy time, complications, quality of life