Research Article

Plasma YKL-40 Elevation on Admission and Follow-Up Is Associated with Diastolic Dysfunction and Mortality in Patients with Acute Myocardial Infarction

Table 1

Demographic characteristics of the patients which were divided into 2 groups by median YKL-40 level on admission.

Patients with plasma YKL-40 below the median valuePatients with plasma YKL-40 above the median value

Age, years54 ± 963 ± 110.01
Gender, male, n (%)21/23 (91%)18/23 (78%)0.21
Hypertension, n/total (%)10/23 (43%)8/23 (35%)0.54
Diabetes mellitus, n/total (%)5/23 (22%)7/23 (30%)0.50
CVH history, n/total (%)8/23 (34%)10/23 (43%)0.24
Hyperlipidemia, n/total (%)10/23 (43%)4/23 (17%)0.05
Body mass index, kg/m228.9 ± 4.827.7 ± 3.60.35
AF at admission, n/total (%)0/233/23 (13%)0.07
STEMI, n (%)
Non-STEMI, n (%)
11 (48%)
12 (52%)
13 (56%)
10 (44%)
0.55
Application within office time, n
Application out of office time, n
14 (60%)
9 (40%)
6 (26%)
17 (74%)
0.01
NYHA class I, n/total (%)
NYHA class II-III, n/total (%)
21 (91%)
2 (9%)
12 (52%)
11 (48%)
0.003
Systolic blood pressure142 ± 32134 ± 210.38
Serum glucose, mg/dl113 (92–167)152 (114–246)0.06
Serum creatinine, mg/dl1.05 ± 0.21.2 ± 0.30.06
White blood cell counts11.09 ± 3.610.11 ± 3.70.39
Hemogram, mg/dl14.5 ± 1.613 ± 1.70.09
Log troponin-I 24 hours1.4 ± 0.51.5 ± 0.80.71
Log BNP on admission1.6 ± 0.42.0 ± 0.60.06
First-month log BNP1.8 ± 0.52.1 ± 0.40.04
First-month log YKL-401.7 ± 0.22.0 ± 0.20.004
EF (Simpson’s method), %58 ± 1057 ± 120.31
Tei index0.71 ± 0.260.88 ± 0.280.03
LAVi, ml/m228.9 ± 7.833.1 ± 11.60.15
Mitral lateral e′, cm/s9.3 ± 3.37.7 ± 3.30.11
Lateral E/e′, median (IQR)9.6 (6.4–12.3)9.6 (8.5–18.4)0.14
Mitral septal e′, cm/s7.3 ± 2.55.7 ± 2.00.02
Septal E/e′11.9 ± 4.116.8 ± 7.10.007
RV TDI s′, cm/s14.6 ± 4.312.6 ± 3.40.08
TAPSE, cm2.2 ± 0.42.3 ± 0.60.50
All-cause death2/23 (9%)12/23 (52%)0.001

ASA: acetylsalicylic acid; AF: atrial fibrillation; BNP: brain natriuretic peptide; CVH: cardiovascular hastalık; EF: ejection fraction; LAVi: left atrium volume index; NYHA: New York Heart Association; RV: right ventricle; STEMI: ST elevation myocardial infarction.