Thiol/Disulfide Balance in Patients with Familial Hypercholesterolemia

Table 1

The mean and p values of parameters of patient and control groups.

Parameter	Patient group	Control group
	Mean ± SD	Mean ± SD
Age	47.03 ± 12.67	46.83 ± 6.06	0.903
Gender (female-male)	(74–7)	(32–19)	0.001
Waist circumference	91.06 ± 11.8	94.53 ± 9.41	0.078
BMI	29.10 ± 5.10	29.85 ± 5.16	0.427
N. thiol	305.52 ± 71.33	389.85 ± 63.31	0.001
T. thiol	335.33 ± 78.19	410.32 ± 63.95	0.001
Disulfide	18.03 ± 15.78	10.68 ± 5.87	0.004
%SS/SH	5.76 ± 4.23	2.79 ± 1.37	0.001
%SS/total SH	15.65 ± 76.47	2.63 ± 1.22	0.001
%SH/total SH	91.36 ± 5.16	94.90 ± 1.90	0.001
CRP	4.21 ± 5.20	1.65 ± 2.02	0.001
T. protein (g/dl)	7.34 ± 0.49	21.04 ± 22.45	0.007
Albumin (g/dl)	4.43 ± 0.29	18.73 ± 12.37	0.001
FGL (mg/dl)	92.38 ± 17.65	113.26 ± 54.82	0.013
Creatinine (mg/dl)	0.75 ± 0.14	0.69 ± 0.17	0.343
ALT (U/l)	27.18 ± 16.12	37.58 ± 56.19	0.060
AST (U/l)	23.42 ± 8.12	96.73 ± 70.93	0.002
GGT (U/l)	38.13 ± 29.86	13.18 ± 19.87	0.038
ALP (U/l)	81.26 ± 24.40	26.98 ± 49.54	0.007
Uric acid (mg/dl)	5.62 ± 1.15	4.16 ± 1.67	0.001
T. cholesterol (mg/dl)	339.52 ± 66.54	217.60 ± 74.56	0.004
Triglyceride (mg/dl)	191.74 ± 80.52	168.07 ± 94.58	0.523
HDL (mg/dl)	49.35 ± 9.30	53.78 ± 22.24	0.880
LDL (mg/dl)	251.22 ± 51.86	131.96 ± 44.01	0.001
TSH (uU/ml)	1.70 ± 0.94	1.55 ± 1.22	0.494

ALP: alkaline phosphatase; ALT: alanine aminotransferase; AST: aspartate aminotransferase; BMI: body mass index; CRP: C-reactive protein; FGL: fasting glucose level; HDL: high-density lipoprotein; LDL: low-density lipoprotein; N. thiol: native thiol; T. thiol: total thiol; T. protein: total protein; T. cholesterol: total cholesterol; TSH: thyroid stimulating hormone.