Genetic Variants Are Not Rare in ICD Candidates with Dilated Cardiomyopathy: Time for Next-Generation Sequencing?

Table 2

Clinical characteristics of patients with genetic variants.

Case	Gender	Age	Age at diagnosis	NYHA class	Etiology	ECG-rhythm disturbances	ECG-conduction disturbances	LVEF (%)	LVED (mm)	Affected gene
1	Female	40	17	II	IDCM	SR	—	38	61	TPM1
2	Male	53	38	II	IDCM	SR	LBBB	38	63	TNNT2
3	Male	55	53	II	IDCM	SR	LBBB	39	56^†	MYH7
4	Female	56	47	I	FDCM^‡	SR	—	37	68	PLN
5	Male	53	41	II	FDCM^‡	SR	—	33	62	PLN
6	Female	72	58	II	FDCM	AF	LBBB	20	71	MYBPC3

FDCM: familial dilated cardiomyopathy; IDCM: idiopathic dilated cardiomyopathy; LBBB: left bundle branch block; LVED: left ventricular end-diastolic diameter; LVEF: left ventricular ejection fraction; SR: sinus rhythm; serum creatine kinase elevation; ^†left ventricular hypertrabeculation/noncompaction; ^‡sudden death in relatives.