Clinical Value of Asymmetrical Dimethylarginine Detection in Patients with Connective Tissue Disease-Associated Pulmonary Arterial Hypertension

Table 1

Baseline clinical data of CTD patients.

Parameters	Normal sPAP (n = 45)	Abnormal sPAP (N = 43)	value
Chest tightness (n, %)	6 (13.3)	18 (41.9)	0.003
Raynaud’s phenomenon (n, %)	6 (13.3)	14 (32.6)	0.031
Cough (n, %)	9 (20.0)	13 (30.2)	0.268
ESR (, mm/h)	24 (16, 46)	40 (19, 60)	0.199
CRP (M(QR), mg/L)	3.49 (1.95, 22.60)	11.5 (4.60, 28.05)	0.034
PLT (, L)	214.8 ± 71.29	177.3 ± 83.4	0.026
MPV (M(QR), fl)	10.6 (9.8, 11.7)	11.3 (10.4, 12.8)	0.021
RDW (M(QR), %)	13.4 (12.8, 14.8)	13.9 (13.2, 15.9)	0.191
TBIL (M(QR), μmol/L)	9.1 (7.4, 11.3)	12.4 (9.8, 14.2)	<0.001
UA (M(QR), μmol/L)	262.5 (230.3, 298.0)	308.0 (244.0, 439.0)	0.013
Hcy (M(QR), μmol/L)	10.2 (7.3, 11.7)	12.5 (10.3, 15.4)	0.001
LDH (M(QR), U/L)	191.0 (159.8, 277.0)	204.5 (169.3, 298.8)	0.517
Ferritin (M(QR), ng/ml)	132.95 (74.55, 312.68)	224.00 (122.50, 412.40)	0.043
D-D (M(QR), mg/L)	0.46 (0.21, 1.60)	0.87 (0.48, 1.46)	0.065
FDP (M(QR), mg/L)	2.96 (1.13, 6.19)	4.02 (2.23, 7.99)	0.077
NT-proBNP (M(QR), pg/ml)	337.0 (144.0, 594.0)	522.0 (353.0, 713.3)	0.003
C3 (M(QR), g/L)	0.82 (0.61, 0.93)	0.76 (0.55, 0.99)	0.871
C4 (M(QR), g/L)	0.17 (0.12, 0.20)	0.16 (0.12, 0.23)	0.816
IgG (M(QR), g/L)	12.70 (8.82, 18.30)	12.40 (10.20, 16.40)	0.767
IgM (M(QR), g/L)	1.12 (0.57, 1.62)	0.97 (0.69, 1.71)	0.802
IgA (M(QR), g/L)	2.47 (1.54, 3.55)	2.30 (1.20, 3.34)	0.695
Autoimmune-related antibodies^a (n, %)	28 (62.2)	24 (55.8)	0.541

^aAntinuclear antibody positive, or at least one autoantibody appears in the antinuclear antibody spectrum; ESR: erythrocyte sedimentation rate; CRP: C-reactive protein; HGB: hemoglobin; PLT: platelets; MPV: mean platelet volume; Hct: hematocrit; RDW: erythrocyte hemoglobin distribution width; TBIL: total bilirubin; UA: uric acid; Hcy: homocysteine; LDH: lactate dehydrogenase; D-D: D-dimer; FDP: fibrin degradation product; NT-proBNP: N-terminal pro-brain natriuretic peptide; IgG: immunoglobulin G; IgM: immunoglobulin M; IgA: immunoglobulin A; .