Does Arterial Hypertension Affect Plasma Levels of Matrix Metalloproteinases and Their Tissue Inhibitors in Patients with Stable Coronary Artery Disease? A Preliminary Study

Table 4

Influence of DM on plasma levels of MMP-2, MMP-9, and TIMP-4.

	CAD + HT + DM +	Control	value	CAD + HT + DM +	CAD + HT + DM−	value
MMP-2 (ng/ml)	175.6 ± 61.5	165.7 ± 19.1	0.81	175.6 ± 61.5	133.8 ± 23.4	0.0025
MMP-9 (ng/ml)	50.8 ± 28.4	47.2 ± 22.3	0.67	50.8 ± 28.4	40.9 ± 23.3	0.16
TIMP-4 (pg/ml)	1679.6 ± 784.2	1153.2 ± 339.9	0.0099	1679.6 ± 784.2	1573.1 ± 765.6	0.60

CAD + HT + DM + : group of patients suffering from coronary artery disease, hypertension, and diabetes; CAD + HT + DM−: group of patients suffering from coronary artery disease and hypertension without diabetes; MMP-2: matrix metalloproteinase-2; MMP-9: matrix metalloproteinase-9; TIMP-4: tissue inhibitor of metalloproteinases 4. Mean ± SEM. Statistical tests used: Mann–Whitney U test and unpaired t-test.