Leukodepleted Packed Red Blood Cells Transfusion in Patients Undergoing Major Cardiovascular Surgical Procedure: Systematic Review and Meta-Analysis

Table 1

Characteristics of the included studies.

ID	Country	Age mean by group (LD, C)	Male (%)	Leukodepleted group				Comparator group		Cointerventions
				Transfused patients,	Type of surgery	Leukodepleted definition	Filter	Transfused patients,	Comparator
Bilgin et al. 2004 [6]	Netherlands	65.3, 66.6	53 to 57	216	Cardiac valve surgery with or without coronary artery bypass graft	0.15 ± 0.02 × 10^6 per unit	Cellselect-Optima	216	Buffy coat depleted packed cells	Platelets
Boshkov et al. 2006 [38]	USA	Unclear	Unclear	304	Coronary artery bypass graft and/or cardiac valve replacement	Unclear	Unclear	258	Standard RBC	No
Bracey et al. 2002 [39]	USA	Unclear	Unclear	170	Open-heart surgery, coronary artery bypass graft, and valve replacement	Unclear	Unclear	187	Standard RBC	Unclear
Connery et al. 2005 [8]	USA	62.9, 66	71 to 74.2	38	Coronary artery bypass graft	Unclear	Unclear	31	Standard RBC	Platelets
van de Watering et al. 1998 [3]	Netherlands	62.9, 64.4	72.2 to 73.7	287	Coronary artery bypass graft and/or cardiac valve surgery	1.2 ± 1.4 × 10^6 per unit	Cellselect-optima	294	Buffy coat depleted packed cells	No
van Hilten et al. 2004 [7]	Netherlands	66, 71	Unclear	133	Acute aneurysm surgery and elective aneurysm surgery	Unclear	Unclear	128	Buffy coat depleted packed cells	No
Wallis et al. 2002 [5]	UK	61.7, 62.4	Ratio men/women: 2.6 to 2.9	176	Coronary artery bypass graft and/or cardiac valve surgery	5 × 10^6 per unit	BPF4	333	Buffy coat depleted packed cells and red blood cells concentrate with plasma reduction	No

RBCs = red blood cells. LD: leukodepleted group; C: comparator group.