The Expression Profile of MicroRNAs in Small and Large Abdominal Aortic Aneurysms

Table 3

miRNAs with more than two-fold significant change in expression in large aneurysm tissue, vascular biology processes in which they are involved, and their target genes.

miRNA	Process/function	Target genes	Reference no
miR-23	Angiogenesis (proangiogenic)	E2F1	[11]
	VSMCs proliferation		[12]
	Apoptosis (antiapoptotic)	BCL2L11 (BIM)	[12]
miR-24	Angiogenesis (antiangiogenic)	GATA2	[11]
	Apoptosis	GATA2, PAK4, BIM	[11]
	Mediator of contractile phenotype in VSMCs	Trb3	[11]
	Inhibits proliferation, migration and sprouting		[14]
	Vascular inflammation and AAA pathology		[10, 15]
miR-27	Angiogenesis (proangiogenic)	SEMA6A, SEMA6D, SPROUTY2, TSP-1, MMP-13	[11, 13]
	Endothelial cell growth inhibition	Rb	[11]
	Inflammation	MMP-13, VEGF, TSG-1	[13]
	Apoptosis	FADD	[13]
	Atherosclerosis	G2A	[13]
miR-30	Angiogenesis	DLL4	[17]
	Endoplasmic reticulum (ER) stress; cell death	GRP78, ATF6, CHOP, CASP12	[19]
miR-193	Angiogenesis (antiangiogenic)	HMGB1	[24]
miR-203	Inflammation	SOCS-3	[28, 29]
miR-365	Apoptosis	BCL2	[25]
	Atherosclerosis	BCL2	[25]
miR-3663	Downregulated in degenerative aortic stenosis	NA	[30]
miR-4291	NA	NA	—

ATF6: activating transcription factor 6; BCL2L11 (BIM): Bcl-2; CASP12: caspase-12; DLL4: δ-like ligand 4; E2F1: E2F1 transcription factor; FADD: Fas-associated protein with death domain; G2A: G protein-coupled receptor 132; GRP78: glucose-regulated protein 78; HMGB1: High mobility group box-1; CHOP: CCAAT-enhancer-binding protein homologous protein; MMP-13: matrix metalloproteinase 13; SEMA6A: semaphorin 6a; SEMA6D: semaphorin 6d; SPROUTY2: sprouty homolog 2; Trb3: tribbles-like protein-3; TSG-1: thrombospondin-1; TSP-1thrombospondin-1; VEGF: vascular endothelial growth factor; VSMCs: vascular smooth muscle cells.