Prognostic Significance of Chronic Kidney Disease (CKD-EPI Equation) and Anemia in Patients with Chronic Heart Failure Secondary to Chagas Cardiomyopathy
Table 2
Association between chronic kidney disease or anemia and other baseline characteristics.
Baseline characteristics
CKD (N = 98)
Non-CKD (N = 134)
value
Anemic (N = 41)
Nonanemic (N = 191)
value
Median (25th–75th) or N (%)
Median (25th–75th) or N (%)
Clinical parameters
Age (years)
63 (54–68)
52 (42–60)
<0.001
63 (52–70)
55 (44–64)
0.010
Gender (male)
59 (60.2)
94 (70.1)
0.114
32 (78.0)
121 (63.4)
0.720
NYHA classes I and II
61 (62.2)
96 (71.6)
0.171
25 (61.0)
132 (69.1)
0.323
NYHA classes III and IV
37 (37.8)
38 (28.4)
16 (39.0)
59 (30.9)
Heart rate (beats/min)
66 (60–74)
70 (60–80)
0.026
70 (60–79)
68 (60–80)
0.873
Systolic blood pressure (mmHg)
100 (90–120)
110 (100–120)
0.150
110 (90–120)
110 (100–120)
0.640
Diastolic blood pressure (mmHg)
70 (60–70)
70 (60–80)
0.097
70 (60–80)
70 (60–80)
0.523
Type 2 diabetes mellitus
4 (4.1)
7 (5.2)
0.764
0 (0.0)
11 (5.8)
0.220
Laboratory analysis
Sodium (mEq/L)
141 (137–144)
141 (138–144)
0.388
141 (135–145)
141 (138–144)
0.807
Potassium (mEq/L)
4.3 (4.0–4.7)
4.4 (4.1–4.8)
0.452
4.4 (4.1–4.9)
4.3 (4.0–4.8)
0.551
12-lead resting electrocardiography
Atrial fibrillation
30 (30.3)
33 (24.6)
0.311
13 (31.7)
50 (26.2)
0.470
ICD
10 (10.2)
16 (11.9)
0.679
5 (12.2)
21 (11.0)
0.788
Pacemaker
65 (66.3)
59 (44.0)
0.001
27 (65.9)
97 (50.8)
0.079
Left bundle branch block
12 (12.2)
25 (18.7)
0.188
7 (17.1)
30 (15.7)
0.828
Right bundle branch block
37 (37.8)
56 (41.8)
0.536
21 (51.2)
72 (37.7)
0.109
Left anterior fascicular block
36 (36.7)
55 (41.0)
0.507
16 (39.0)
75 (39.3)
0.977
Low voltage of QRS
4 (4.1)
8 (6.0)
0.521
3 (7.3)
9 (4.7)
0.449
Ventricular premature contraction
41 (41.8)
67(50.0)
0.218
24 (58.5)
84 (44.0)
0.090
2D-ecochardiography
Left ventricular end-diastolic diameter (mm)
66 (60–71)
65 (59–71)
0.497
64 (59–74)
65 (59–71)
0.856
Left ventricular systolic diameter (mm)
56 (50–62)
55 (50–61)
0.544
56 (47–64)
55 (50–61)
0.839
Right ventricular diameter (mm)
27 (22–31)
23 (18–30)
0.011
25 (20–31)
24 (20–30)
0.650
Wall motion abnormalities
32 (32.7)
46 (34.3)
0.790
10 (24.4)
68 (35.6)
0.168
Left ventricular apical aneurysm
5 (5.1)
10 (7.5)
0.470
2 (4.9)
13 (6.8)
1.000
Left ventricular ejection fraction (%)
32.0 (23.7–39.0)
31.7 (25.0–40.8)
0.462
31.1 (24.4–38.3)
31.7 (24.4–40.1)
0.590
CKD: chronic kidney disease; N: number of individuals; NYHA: New York Heart Association Functional Class; ICD: implantable cardioverter-defibrillator.
