Association of Biomarker Level with Cardiovascular Events: Results of a 4-Year Follow-Up Study

Table 4

Results of a single-factor and multiple-factor COX regression analysis to estimate risk factors of a “composite endpoint” among people who are not known to have cardiovascular events.

Variable	cOR (95% CI)		aOR (95% CI)
Composite endpoint (EP)
Age, years	1.07 (1.02–1.12)	0.004	1.06 (1.006–1.11)	0.028
Gender, male	1.16 (0.53–2.56)	0.71	1.72 (0.70–4.19)	0.237
Smoking	0.29 (0.04–2.14)	0.227	0.27 (0.03–2.18)	0.218
BMI, kg/m^2	1.07 (1.007–1.13)	0.027	—	—
WL, cm	1.025 (1.002–1.050)	0.035	—	—
BMI ∗ WM, kg/m^2cm	—	—	1.001 (1.000–1.001)	0.084
SBP, mmHg	2.09 (1.07–4.07)	0.031	1.03 (1.005–1.06)	0.022
DBP, mmHg	1.47 (0.76–2.85)	0.25	0.96 (0.91–1.01)	0.113
Cholesterol, mmol/l	0.92 (0.44–1.94)	0.84	0.95 (0.70–1.28)	0.736
Glucose, mmol/l	1.80 (0.93–3.50)	0.082	0.98 (0.85–1.14)	0.845
CXCL16 pg/ml	1.002 (1.001–1.003)	≤0.001	1.002 (1.001–1.003)	≤0.001
Endocan, pg/ml	1.001 (1.0–1.001)	0.024	1.001 (1.000–1.001)	0.370
H-FABP, pg/ml	1.000 (1.000–1.000)	0.455	1.000 (1.000–1.000)	0.756
MACE
Age, years	1.07 (0.99–1.16)	0.096	1.02 (0.91–1.15)	0.139
Gender, male	1.18 (0.33–4.24)	0.80	5.22 (0.58–46.7)	0.678
Smoking	1.01 (0.13–7.89)	0.993	0.078 (0.001–18.5)	0.361
BMI, kg/m^2	1.098 (0.99–1.21)	0.073	—	—
WL, cm	1.060 (1.015–1.107)	0.008	—	—
BMIWM, kg/m^2 ∗ cm	—	—	1.001 (1.000–1.1002)	0.028
SBP, mmHg	1.04 (1.018–1.065)	≤0.001	1.10 (1.034–1.18)	0.003
DBP, mmHg	1.043 (1.001–1.088)	0.045	0.916 (0.83–1.02)	0.096
Cholesterol, mmol/l	0.96 (0.58–1.61)	0.881	0.92 (0.92 (0.47–1.83)	0.818
Glucose, mmol/l	1.012 (0.96–1.34)	0.14	0.89 (0.89 (0.67–1.18)	0.415
CXCL16, pg/ml	1.003 (1.002–1.004)	≤0.001	1.004 (1.002–1.006)	≤0.001
Endocan, pg/ml	1.001 (1.000–1.002)	≤0.001	1.002 (1.001–1.004)	0.008
H-FABP, pg/ml	1.000 (1.000–1.000)	0.095	1.000 (1.000–1.000)	0.833