Drug-Coated Balloon versus Drug-Eluting Stent in Patients with Small-Vessel Coronary Artery Disease: A Meta-Analysis of Randomized Controlled Trials

Table 2

Outcomes of included studies.

Study	PICCOLETO [10]		BELLO [11, 12]		BASKET-SMALL2 [13]		RESTORE SVD China [14, 15]
	DCB (n = 28)	DES (n = 29)	DCB (n = 90)	DES (n = 92)	DCB (n = 382)	DES (n = 376）	DCB (n = 116)	DES (n = 114)
MACE (%)	10 (35.7)	4 (13.8)	13 (14.8)	23 (25.3)	28 (7.3)	28 (7.5)	N/A	N/A
Death (%)	1 (3.6)	1 (3.5)	1 (1.1)	2 (2.2)	N/A	N/A	1 (0.9)	1 (0.9)
Cardiac death (%)	0	0	0	0	12 (3.1)	5 (1.3)	0	1 (0.9)
MI (%)	1 (3.6)	0	3 (3.4)	8 (8.8)	6 (1.6)	13 (3.5)	1 (0.9)	1 (0.9)
TLR (%)	9 (32.1)	3 (10.3)	6 (6.8)	11 (12.1)	N/A	N/A	6 (5.2)	3 (3.8)
TVR (%)	9 (32.1)	4 (13.8)	9 (10.2)	16 (17.6)	12 (3.4)	17 (4.5)	7 (6.1)	8 (7.3)
TLF (%)	N/A	N/A	N/A	N/A	N/A	N/A	6 (5.2)	4 (3.7)

DCB, drug-coated balloon; DES, drug-eluting stent; MACE, major adverse cardiac events; MI, myocardial infarction; TLF, target lesion failure; TLR, target lesion revascularization; TVR, target vessel revascularization; SVD, small vessel disease. MACE definition: PICCOLETO: death, new ST-elevation MI, and TLR; BELLO: death, Q- or non-Q-wave MI, or TVR; BASKET-SMALL2: cardiac death, non-fatal MI, and TVR.