Atrial Cardiomyopathy and Atrial Fibrillation in Cancer

Figure 1

Schematic overview of the link between cancer, atrial fibrillation, and atrial cardiomyopathy. Shared factors may predispose to a comorbidity state of cancer, atrial cardiomyopathy, and atrial fibrillation. Cancer may cause atrial fibrillation and atrial cardiomyopathy by anticancer therapy, autonomous nervous system (ANS) imbalance, direct tumor effect, and other abnormalities. These factors may have direct effects on the left atria (LA) substrate and lead to systemic inflammation and apoptosis. Then, they promote or result in fibrosis and structural remodeling, leading new-onset or existing atrial cardiopathy progress to atrial fibrillation.