Cardiology Research and Practice

Cell Signalling Pathways Leading to Novel Therapeutic Strategies in Cardiovascular Disease


Publishing date
15 Dec 2011
Status
Published
Submission deadline
15 Jun 2011

Lead Editor

1Vasoactive Peptide Group, Department of Clinical Research, University of Bern, 3004 Bern, Switzerland

2Centre for Rheumatology and Connective Tissues Diseases, Royal Free Hospital, Pond Street, London, UK

3Vascular Unit, Academic Department of Surgery, Royal Free Hospital, Pond Street, London NW3 2QG, UK

4Division of Surgery and Interventional Science, UCL, Royal Free Campus, Pond Street, London NW3 2QG, UK


Cell Signalling Pathways Leading to Novel Therapeutic Strategies in Cardiovascular Disease

Description

Cardiovascular disease is a major cause of morbidity and mortality worldwide. Studies of regulatory mechanisms controlling key pathological mediators have recently highlighted a previously unrecognized intrinsic link between activation of specific elements of the innate immune system, by endogenous ligands released from cellular compartments in response to tissue injury, and the initiation and progression of vascular inflammation, arteriopathy, and cardiac failure associated with vascular grafts and cardiac transplantation. Identification and further understanding of the molecular mechanisms whereby several risk factors, ischemia, and hemodynamics interact with the immune system to modulate vascular cell function, proliferation, and remodeling, and cell response to injury could facilitate the identification of novel molecular targets with the potential to translate rapidly into innovative therapeutics. Drugs that modulate these systems represent an exciting new area of pharmaceutical development.

We invite authors to submit original research and review articles that address the important challenges and opportunities that exist in this area to exploit developments with the potential to facilitate the implementation of novel therapeutic strategies for the treatment of patients with cardiovascular disease. In addition to outside contributions, participant authors of relevant papers from the “2nd Royal Free International Cardiovascular Diseases Workshop” held at the Royal Free Hospital, London, are encouraged to submit extended versions of their workshop papers to the Special Issue. Potential topics include, but are not limited to:

  • The emerging role of Toll-like receptors in cardiovascular disease
  • Protecting the heart by ischemic preconditioning
  • New aspects of scavenger receptor signaling
  • Nitric oxide and the immune system in cardiovascular disease
  • Tissue repair; metalloproteinase's and tissue inhibitors

Before submission authors should carefully read over the journal's Author Guidelines, which are located at http://www.hindawi.com/journals/crp/guidelines/. Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System at http://mts.hindawi.com/submit/journals/crp/cscd/ according to the following timetable:

Manuscript DueJune 15, 2011
First Round of ReviewsSeptember 15, 2011
Publication DateDecember 15, 2011

Lead Guest Editor

  • Sidney G. Shaw, Vasoactive Peptide Group, Department of Clinical Research, University of Bern, 3004 Bern, Switzerland

Guest Editors

  • David J. Abraham, Centre for Rheumatology and Connective Tissues Diseases, Royal Free Hospital, Pond Street, London, UK
  • Daryll M. Baker, Vascular Unit, Academic Department of Surgery, Royal Free Hospital, Pond Street, London NW3 2QG, UK
  • Janice Tsui, Division of Surgery and Interventional Science, UCL, Royal Free Campus, Pond Street, London NW3 2QG, UK

Articles

  • Special Issue
  • - Volume 2012
  • - Article ID 475094
  • - Editorial

Cell Signalling Pathways Leading to Novel Therapeutic Strategies in Cardiovascular Disease

Sidney G. Shaw | David J. Abraham | ... | Janice Tsui
  • Special Issue
  • - Volume 2012
  • - Article ID 246710
  • - Review Article

The Continuing Challenges of Translational Research: Clinician-Scientists’ Perspective

Shervanthi Homer-Vanniasinkam | Janice Tsui
  • Special Issue
  • - Volume 2012
  • - Article ID 148796
  • - Review Article

Targeted In Situ Gene Correction of Dysfunctional APOE Alleles to Produce Atheroprotective Plasma ApoE3 Protein

Ioannis Papaioannou | J. Paul Simons | James S. Owen
  • Special Issue
  • - Volume 2012
  • - Article ID 971614
  • - Review Article

Cell Therapies for Heart Function Recovery: Focus on Myocardial Tissue Engineering and Nanotechnologies

Marie-Noëlle Giraud | Anne Géraldine Guex | Hendrik T. Tevaearai
  • Special Issue
  • - Volume 2012
  • - Article ID 181394
  • - Review Article

The Emerging Role of TLR and Innate Immunity in Cardiovascular Disease

Rolf Spirig | Janice Tsui | Sidney Shaw
  • Special Issue
  • - Volume 2012
  • - Article ID 656247
  • - Review Article

Nitric Oxide Manipulation: A Therapeutic Target for Peripheral Arterial Disease?

Gareth Williams | Xu Shi-Wen | ... | Janice C. S. Tsui
  • Special Issue
  • - Volume 2012
  • - Article ID 486702
  • - Review Article

MicroRNAs in Postischemic Vascular Repair

Andrea Caporali | Costanza Emanueli
  • Special Issue
  • - Volume 2012
  • - Article ID 496904
  • - Review Article

Connexins and Diabetes

Josephine A. Wright | Toby Richards | David L. Becker
  • Special Issue
  • - Volume 2012
  • - Article ID 845698
  • - Review Article

The Diabetic Heart: Too Sweet for Its Own Good?

Hannah J. Whittington | Girish G. Babu | ... | Derek J. Hausenloy
  • Special Issue
  • - Volume 2012
  • - Article ID 213785
  • - Review Article

Potential of Novel EPO Derivatives in Limb Ischemia

Dhiraj Joshi | Janice Tsui | ... | Daryll M. Baker
Cardiology Research and Practice
 Journal metrics
Acceptance rate26%
Submission to final decision104 days
Acceptance to publication35 days
CiteScore1.970
Impact Factor2.140
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