The rising epidemic of coronary heart disease and the associated complications threaten the population and pose a heavy burden on global public health programs. The last decade has seen an explosion of research in the area of pathogenesis (from biomechanics, cellular components to biomolecular signals), therapeutic and protection strategies of coronary heart disease and its complications. Endothelial injury and repair was confirmed to be related to a variety of cardiovascular events, playing an important role in the prevention and treatment of cardiovascular diseases. Gaps remain in the mechanism of endothelial injury and repair, and its role in coronary heart disease. Advances in research to provide new strategies for endothelial protection in coronary heart disease practice are also our focus.

The purpose of this Special Issue is to provide a platform for the researchers to exhibit their original investigations focused on the endothelial injury and repair pathophysiology, or advances in clinical practice and prevention of endothelial injury in coronary heart disease or its complications. The papers submitted to this special issue include original research articles, review articles, clinical, and experimental studies related to the above topic.

Potential topics include but are not limited to the following:

• Mechanism of endothelial injury and repair in coronary heart disease initiation and progression, or the induced complications
• Endothelial injury and repair in cardiovascular risk factors which lead to coronary heart disease, such as hypertension, diabetes, hypercholesterolemia, obesity
• The influence of lifestyle, including, but not limited to, diet, exercise, smoking, and drugs on endothelial injury and repair contributing to coronary heart disease outcomes
• Mechanisms of cells (e.g. endothelial cell, endothelial progenitor cell, inflammatory cells) or circulating biomarkers (e.g. cytokines, inflammatory factors, endothelial granules, exosomes, microRNA, lcnRNA) in endothelial injury and repair of coronary heart disease
• Effect of biomechanics on endothelial injury and repair, the mechanism in coronary heart disease, and its clinical significance for cardiology practice and prevention
• Pharmacologic treatment, cell therapy, immunotherapy strategies, or medical care for endothelial injury in coronary heart disease
• Other advances in clinical prevention and nursing in coronary heart disease that may be related to endothelial injury