The rising epidemic of coronary heart disease threatens the population and poses a heavy burden on global public health programs. The last decade has seen an explosion of research in the area of pathogenesis (from biomechanics, cellular components, and biomolecular signals), therapeutics, and protection strategies of coronary heart disease. Endothelial injury and repair were demonstrated to be related to a variety of cardiovascular events, playing an important role in the prevention and treatment of cardiovascular diseases. Gaps remain in the mechanism of endothelial injury and repair, and its role in coronary heart disease. We also focus on advances in research providing strategies for endothelial protection in coronary heart disease practice.

The purpose of this special issue is to provide a platform for researchers to exhibit their original investigations focused on the endothelial injury and repair pathophysiology, or advances in clinical practice and prevention of endothelial injury in coronary heart disease. We welcome original research articles, review articles, and clinical and experimental studies related to the above topic.

Potential topics include but are not limited to the following:

• Mechanisms of endothelial injury and repair in coronary heart disease initiation and progression
• Endothelial injury and repair in coronary heart disease associated risk factors, such as hypertension, diabetes, hypercholesterolemia, and obesity
• The influence of lifestyle, including but not limited to, diet, exercise, smoking, and drugs, on endothelial injury and repair, contributing to coronary heart disease outcomes
• Mechanisms of cells (e.g. endothelial cells, endothelial progenitor cells, and inflammatory cells) or cytokines in endothelial injury and repair of coronary heart disease
• Effect of biomechanics on endothelial injury and repair, the mechanism in coronary heart disease, and its clinical significance for cardiology practice and prevention
• Cell therapy or immunotherapy strategies for endothelial injury in coronary heart disease
• Other advances in clinical practice and prevention of endothelial injury in coronary heart disease