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Disease Markers
Volume 11, Issue 1, Pages 29-35

Dna Hla-Drbi Analysis In Children Of Positive Mothers And Estimated Risk Of Vertical Hiv Transmission

N. A. Greggio,1 M. Cameran,1 C. Giaquinto,1 F. Zacchello,1 D. Koroliukt,2 and V. Colizz2

1Department of Pediatrics, University of Padova, Italy
2Department of Biology and Mathematics and Volterra Centre, University of Rome Tor Vergata, Italy

Copyright © 1993 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


RFLP HLA-DRB I analysis was performed on a total of 83 children born from HIV -infected mothers, 35 of whom were shown to be HIV -infected, while 48 reverted from seropositivity to seronegativity, indicating that they were not infected. Moreover, 89 healthy children were used as controls. It has been found that DRBI-14a and DRBI-13a.4 alleles were not present in the HIV-infected children, but were found in the sero-reverted (HIV-uninfected) children (in the proportion of 9·6 per cent and 5·3 per cent, respectively), and in the controls (5·6 per cent and 3·9 per cent, respectively). The possible correlation between DR and risk of HIV transmission from mother to baby was analysed considering every single allele, estimated by the ratio between the number of infected children and the number of all children born from seropositive mothers. There was also introduced a statistic G for the control of ’statistical validity’ of data.