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Disease Markers
Volume 11, Issue 4, Pages 187-190

ABO Genotyping of Complete Hydatidiform Moles

Gerard T. Venneker,1 Leo P. De Waal,2 Wiete Westerhof,1 Joe D'Amaro,1 Gezina M. Th. Schreuder,3 and Syed S. Asghar1

1Department of Dermatology, University of Amsterdam, Academisch Medisch Centrum, Amsterdam, The Netherlands
2Department of Transplantation Immunology, Central Laboratory of the Red Cross Blood Transfusion Services, Amsterdam, The Netherlands
3Department of Immunohaematology and Blood Bank, Leiden University Hospital, Leiden, The Netherlands

Received 30 August 1993

Copyright © 1993 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


This study chanlcterizes the HLA class I and class II antigens in a group of patients with vitiligo and a control group, both of Dutch descent. Earlier reports had shown a significant positive association with DR4 and a significant negative association with DR3. We found that, after correction for the broad antigens studied, only Cw7 and DR6 were significantly associated with vitiligo. The significant positive association of DR6 with vitiligo is interesting since vitiligo has an autoimmune component in its pathogenesis and DR6 may be a marker for high immune responsiveness.