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Disease Markers
Volume 11, Issue 1, Pages 37-44

HLA-DPAI aND HLA-DPBl in Rheumatoid Arthritis And Its Subsets

C. J. Hutchlngs,1 M. C. Hillarby,1 M. J. Mcmahon,2 W. E. R. Ollier,2 and D. M. Grennan1

1University of Manchester Rheumatic Diseases Centre, Clinical Sciences Building, Hope Hospital, Eccles Old Road, Salford M6 8HD, UK
2ARC Epidemiology Research Unit, Stopford Building, Oxford Road, University of Manchester, Manchester M13 9PT, UK

Copyright © 1993 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The aim of this study was to examine the relationship between HLA-DP and susceptibility to articular and extra-articular features (Felty's syndrome and vasculitis) of rheumatoid arthritis (RA). The possible association of DP types with severity of articular disease was also analysed. No statistically significant associations were observed between HLA-DP alleles and articular or extra-articular features of RA, or to the severity of the arthritis when p was corrected for the number of alleles tested.