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Disease Markers
Volume 11, Issue 2-3, Pages 131-137

Association between Hlaantigens and Progression of HIV Infection in Greek Haemophiliacs

Chr. Papasteriades,1 J. Economidou,1 H. Pappas,1 K. Psarra,1 V. Kapsimali,1 K. Karafoulidou,2 T. Mandalaki,2 and G. Papaevangelou3

1Dept. of Immunology and Histocompatibility, Evangelismos Hospital, Athens, Greece
2Haemophilia Centre, Laikon General Hospital, Athens, Greece
3AIDS Reference Centre, Athens School of Hygiene, Athens, Greece

Received 3 December 1992

Copyright © 1993 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The frequencies of HLA antigens in 33 HIV seronegative and in 88 HIV seropositive haemophiliacs, who have been followed for at least 6 years since seroconversion or first HIV positive test. were evaluated in relation to disease susceptibility and disease progression. A high frequency of HLA-A2 and -DR2 antigens and a low frequency of HLA-A9 were found to characterize HIV seropositive patients (p<0.05). Progressors to symptomatic CDC stage IV had a higher frequency of HLA-A9 (p<0.01) and DR3. Rapid decline of CD4+ T cells in these patients was associated with HLA-A9, -DR I and DR3. Our data suggest that HLA antigens may contribute to susceptibility to HIV infection and disease progression in Greek haemophiliacs.