Disease Markers

Disease Markers / 1994 / Article

Open Access

Volume 12 |Article ID 629152 | https://doi.org/10.1155/1994/629152

M. F. Boy, G. La Nasa, A. Balestrieri, M. V. Cherchi, P. Usai, "Distribution of HLA-DPBl, -DQBI-DQAl Alleles among Sardinian Celiac Patients", Disease Markers, vol. 12, Article ID 629152, 6 pages, 1994. https://doi.org/10.1155/1994/629152

Distribution of HLA-DPBl, -DQBI-DQAl Alleles among Sardinian Celiac Patients

Received29 Aug 1994


The Sardinian population in many aspects differs from other Caucasoid populations, particularly for its degree of homogeneity. For this reason we have studied 50 adult Sardinian patients with celiac disease (CD) and 50 control healthy Sardinian individuals by RFLP analysis and by extensive oligotyping for 17 HLA-DPB 1, 8-DQB I and 9-DQA 1 alleles, and established their -DPB I alleles and -DQB I -DQA I genotypes. The heterodimer HLA-DQB 1 *0201/-DQA 1 *0501, present in 96% of our patients, is strongly associated with CD susceptibility, confirming published reports. On the other hand we found in 11 of 50 probands (22%) the presence of the allele -DQB 1 *05021 DQA1*0102. This genotype is extremely rare in other Caucasian populations and appears to confer limited protection in CD Sardinian patients.

Copyright © 1994 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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