Disease Markers

Disease Markers / 1996 / Article

Open Access

Volume 13 |Article ID 875653 | https://doi.org/10.1155/1996/875653

H.B. Rasmussen, Knud Christensent, J. Clausen, "Sequencing and Detection of Polymorphisms in the 5' End of the Human Endogenous Retroviral Element, HRES-l", Disease Markers, vol. 13, Article ID 875653, 9 pages, 1996. https://doi.org/10.1155/1996/875653

Sequencing and Detection of Polymorphisms in the 5' End of the Human Endogenous Retroviral Element, HRES-l

Received23 Jan 1996


Fragments of the 5’ long terminal repeat (L TR) of the human endogenous retroviral element, HRES-I, were amplified. Single strand conformation analysis of these fragments in combination with sequencing revealed two polymorphic nucleotides, namely a HindIII and an Eco57I polymorphic site. Moreover, a number of differences from the previously published HRES-l L TR sequence were detected. The linkage pattern of the two polymorph isms suggested the existence of three allelic forms of HRES-l. The frequencies of the genotypes and alleles of HRES-I were determined in 158 individuals. The detection of HRES-I markers may be useful to study associations between this endogenous retrovirus and various diseases.

Copyright © 1996 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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