H.B. Rasmussen, Knud Christensent, J. Clausen, "Sequencing and Detection of Polymorphisms in the 5' End of the Human Endogenous Retroviral Element, HRES-l", Disease Markers, vol. 13, Article ID 875653, 9 pages, 1996. https://doi.org/10.1155/1996/875653
Sequencing and Detection of Polymorphisms in the 5' End of the Human Endogenous Retroviral Element, HRES-l
Fragments of the 5’ long terminal repeat (L TR) of the human endogenous retroviral element, HRES-I, were amplified. Single strand conformation analysis of these fragments in combination with sequencing revealed two polymorphic nucleotides, namely a HindIII and an Eco57I polymorphic site. Moreover, a number of differences from the previously published HRES-l L TR sequence were detected. The linkage pattern of the two polymorph isms suggested the existence of three allelic forms of HRES-l. The frequencies of the genotypes and alleles of HRES-I were determined in 158 individuals. The detection of HRES-I markers may be useful to study associations between this endogenous retrovirus and various diseases.
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