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Disease Markers
Volume 14, Issue 2, Pages 121-125

Phosphotyrosine-Protein-Phosphatase and Diabetic Disorders. Further Studies on the Relationship between Low Molecular Weight Acid Phosphatase Genotype and Degree of Glycemic Control

N. Lucarini,1 E. Antonacci,2 N. Bottini,3 P. Borgiani,4 G. Faggioni,1 and F. Gloria-Bottini4

1Department of MCA Biology, University of Camerino, School of Science, Camerino, Italy
2Center of Diabetology, USSL, Penne, Italy
3Chair of Allergology and Clinical Immunology, University of Rome Tor Vergata, School of Medicine, Rome, Italy
4Chair of Preventive and Social Pediatrics, University of Rome Tor Vergata, School of Medicine, Rome, Italy

Received 9 December 1999; Accepted 9 December 1999

Copyright © 1998 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


We have studied a new sample of 276 NIDDM patients from the population of Penne (Italy). Comparison of the new data with those of 214 diabetic pregnant women from the population of Rome reported in a previous paper has shown that the pattern of association between low molecular weight acid phosphatase genotype and degree of glycemic control is similar in the two classes of diabetic patients.

Among nonobese subjects the proportion of ACP1*A (the allele showing the lowest enzymatic activity) is lower in diabetic patients with high glycemic levels (mean value greater than 8.9 mmol/l) than in diabetic patients with a low glycemic level (mean value less than 8.9 mmol/l). Among obese subjects no significant association is observed between glycemic levels and ACP1. Among nonobese subjects the concentration of f isoform of ACP1 is higher in patients showing a high glycemic level than in patients showing a low glycemic level. No significant difference is observed for s isoform.