Disease Markers

Disease Markers / 1998 / Article

Open Access

Volume 14 |Article ID 705857 | https://doi.org/10.1155/1998/705857

P. Cucchi-Mouillot, S. Lai, C. Carcassi, P. Sorba, M. Stuart-Simoni, J.-P. Amoros, B. Genetet, D. Haras, L. Contu, "Implication of HLA-DMA Alleles in Corsican IDDM", Disease Markers, vol. 14, Article ID 705857, 7 pages, 1998. https://doi.org/10.1155/1998/705857

Implication of HLA-DMA Alleles in Corsican IDDM

Received09 Dec 1999
Accepted09 Dec 1999

Abstract

The HLA-DM molecule catalyses the CLIP/antigen peptide exchange in the classical class II peptide-binding groove. As such, DM is an antigen presentation regulator and may be linked to autoimmune diseases. Using PCR derived methods, a relationship was revealed between DM gene polymorphism and IDDM, in a Corsican population. The DMA*0101 allele was observed to confer a significant predisposition to this autoimmune disease while the DMA*0102 allele protected significantly. Experiments examining polymorphism of the HLA-DRB1 gene established that these relationships are not a consequence of linkage disequilibrium with HLA-DRB1 alleles implicated in this pathology. The study of the DMA gene could therefore be an additional tool for early IDDM diagnosis in the Corsican population.

Copyright © 1998 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


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