P. Cucchi-Mouillot, S. Lai, C. Carcassi, P. Sorba, M. Stuart-Simoni, J.-P. Amoros, B. Genetet, D. Haras, L. Contu, "Implication of HLA-DMA Alleles in Corsican IDDM", Disease Markers, vol. 14, Article ID 705857, 7 pages, 1998. https://doi.org/10.1155/1998/705857
Implication of HLA-DMA Alleles in Corsican IDDM
The HLA-DM molecule catalyses the CLIP/antigen peptide exchange in the classical class II peptide-binding groove. As such, DM is an antigen presentation regulator and may be linked to autoimmune diseases. Using PCR derived methods, a relationship was revealed between DM gene polymorphism and IDDM, in a Corsican population. The DMA*0101 allele was observed to confer a significant predisposition to this autoimmune disease while the DMA*0102 allele protected significantly. Experiments examining polymorphism of the HLA-DRB1 gene established that these relationships are not a consequence of linkage disequilibrium with HLA-DRB1 alleles implicated in this pathology. The study of the DMA gene could therefore be an additional tool for early IDDM diagnosis in the Corsican population.
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