Disease Markers

Disease Markers / 1998 / Article

Short Communication | Open Access

Volume 13 |Article ID 867620 | https://doi.org/10.1155/1998/867620

Andrew J. Sandford, Tabassum Chagani, Tracey D. Weir, Peter D. Parè, "α1-Antichymotrypsin Mutations In Patients With Chronic Obstructive Pulmonary Disease", Disease Markers, vol. 13, Article ID 867620, 9 pages, 1998. https://doi.org/10.1155/1998/867620

α1-Antichymotrypsin Mutations In Patients With Chronic Obstructive Pulmonary Disease

Received08 Sep 1997


Mutations in the α1-antichymotrypsin gene have been described which result in reduced levels of α1-antichymotrypsin in the serum. Previous studies have suggested that two of these mutations (Pro227→Ala and Leu55→Pro) predispose to chronic obstructive pulmonary disease (COPD). We have investigated the prevalence of these mutations in 168 COPD patients and 61 controls without airflow obstruction. The prevalence of the Pro227→Ala mutation was 0.9% and it was not associated with impaired lung function. None of the subjects had the Leu 55→Pro mutation.

Copyright © 1998 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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