Table of Contents Author Guidelines Submit a Manuscript
Disease Markers
Volume 16 (2000), Issue 3-4, Pages 163-166
http://dx.doi.org/10.1155/2000/101739
Short report

Inflammatory Bowel Disease: Are There Gender Differences in the Genetics of Signal Transduction? A Preliminary Study of Cytosolic Low Molecular Weight Protein Tyrosine Phosphatase

Nunzio Bottini,1 Fulvia Gloria-Bottini,2 Nazzareno Lucarini,3 Pier Giulio Ronchetti,4 and Luigi Fontana1

1Division of Allergology and Clinical Immunology, University of Rome Tor Vergata School of Medicine, Rome, Italy
2Division of Preventive and Social Pediatrics, University of Rome Tor Vergata School of Medicine, Rome, Italy
3Department of MCA Biology, University of Camerino School of Science, Camerino, Italy
4Division of Gastroenterology, S. Camillo Hospital, Rome, Italy

Received 14 August 2000; Accepted 25 February 2001

Copyright © 2000 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The phenotype of cytosolic Low Molecular Weight Protein Tyrosine Phosphatase (cLMWPTP or ACP1), an enzyme involved in signal transduction of insulin, PDGF and T-cell receptors, has been determined in 71 patients with Crohn's Disease (CD: 37 males and 34 females), 49 patients with Ulcerative Colitis (UC: 27 males and 22 females) and 358 consecutive newborns (194 males and 164 females). cLMWPTP phenotypes showing a high concentration of F isoforms are associated with CD in females and with UC in males. Since PTPases counteract the effects of protein tyrosines kinases, a high concentration of F isoform of cLMWPTP may influence the mucosal response to pathogenic factors, increasing susceptibility to CD in females and to UC in males.