Disease Markers

Disease Markers / 2000 / Article

Open Access

Volume 16 |Article ID 305940 | https://doi.org/10.1155/2000/305940

Essam A. Mady, Ezz El-Din H. Ramadan, Alaa A. Ossman, "Sex Steroid Hormones in Serum and Tissue of Benign and Malignant Breast Tumor Patients", Disease Markers, vol. 16, Article ID 305940, 7 pages, 2000. https://doi.org/10.1155/2000/305940

Sex Steroid Hormones in Serum and Tissue of Benign and Malignant Breast Tumor Patients

Received04 May 2000
Accepted01 Oct 2000

Abstract

The ability of breast tumors to synthesize sex steroid hormones is well recognized and their local production is thought to play a role in breast cancer development and growth. The aim of this study was to estimate local intra-tumoral and circulating levels of Estrone (E1), Estrone Sulfate (E1S), Estradiol (E2), Estriol (E3), and Testosterone (T) in 33 pre- and postmenopausal women with primary breast cancer in comparison to 12 pre- and postmenopausal women with benign breast tumors. The mean levels of the studied sex hormones were higher in serum and tumor tissue of breast cancer women than those with benign breast tumors apart from Testosterone which showed a significant decrease in pre- and postmenopausal women with breast cancer (P < 0.001 for follicular phase, P < 0.001 for luteal phase, and P < 0.001 for postmenopausal). The levels of the five hormones were significantly higher intra-tumoral than in serum of both benign and malignant breast tumor women with E1S as the predominant estrogen. There was only a positive significant correlation between serum and tumor tissue levels of E1 (rs = 0.52, P < 0.05 for follicular; rs = 0.63, P < 0.05 for luteal and rs = 0.58, P < 0.05 for postmenopausal) and a significant correlation between serum and tumor tissue of T (rs = 0.64, P < 0.05 for follicular; rs = -0.51, P < 0.05 for luteal and rs = -0.81, P < 0.04 for postmenopausal).

Copyright © 2000 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


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