ANX7 as a Bio-Marker in Prostate and Breast Cancer Progression

Srivastava, Meera; Bubendorf, Lukas; Nolan, Lisa; Glasman, Mirta; Leighton, Ximena; Miller, Georgina; Fehrle, Wilfred; Raffeld, Mark; Eidelman, Ofer; Kallioniemi, Olli P.; Srivastava, Shiv; Pollard, Harvey B.

doi:https://doi.org/10.1155/2001/239602

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Volume 17 | Article ID 239602 | https://doi.org/10.1155/2001/239602

ANX7 as a Bio-Marker in Prostate and Breast Cancer Progression

Meera Srivastava,¹Lukas Bubendorf,^2,5Lisa Nolan,¹Mirta Glasman,¹Ximena Leighton,¹Georgina Miller,³Wilfred Fehrle,⁴Mark Raffeld,⁴Ofer Eidelman,¹Olli P. Kallioniemi,²Shiv Srivastava,⁶and Harvey B. Pollard¹

Received20 Sept 2001

Accepted20 Sept 2001

Abstract

The ANX7 gene codes for a Ca²⁺-activated GTPase, which has been implicated in both exocytotic secretion in cells and control of growth. In this review, we summarize information regarding increased tumor frequency in the Anx7 knockout mice, ANX7 growth suppression of human cancer cell lines, and ANX7 expression in human tumor tissue micro-arrays. The loss of ANX7 is significant in metastatic and hormone refractory prostate cancer compared to benign prostatic hyperplasia. In addition, ANX7 expression has prognostic value for predicting survival of breast cancer patients.

Copyright

Copyright © 2001 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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