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Disease Markers
Volume 17, Issue 4, Pages 271-284
http://dx.doi.org/10.1155/2001/607263

Proteomics as the Tool to Search for Lung Disease Markers in Bronchoalveolar Lavage

Isabelle Noël-Georis,1 A. Bernard,2 Paul Falmagne,1 and Ruddy Wattiez1

1Laboratoire de Chimie Biologique, Université de Mons-Hainaut, avenue du Champ de Mars 6, B-7000 Mons, Belgium
2Unite de Toxicologie Industrielle et de Médecine du Travail, Université Catholique de Louvain, Clos Chapelle-aux-Champs, B-1200 Bruxelles, Belgium

Received 19 November 2001; Accepted 19 November 2001

Copyright © 2001 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Most lung disorders are known to be associated to considerable modifications of surfactant composition. Numerous of these abnormalities have been exploited in the past to diagnose lung diseases, allowing proper treatment and follow-up. Diagnosis was then based on phospholipid content, surface tension and cytological features of the epithelial lining fluid (ELF), sampled by bronchoalveolar lavage (BAL) during fiberoscopic bronchoscopy. Today, it appears that the protein content of ELF displays a remarkably high complexity, not only due to the wide variety of the proteins it contains but also because of the great diversity of their cellular origins. The significance of the use of proteome analysis of BAL fluid for the search for new lung disease marker proteins and for their simultaneous display and analysis in patients suffering from lung disorders has been examined.