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Disease Markers
Volume 18 (2002), Issue 5-6, Pages 249-268

Emerging Ultrasound Technologies for Early Markers of Disease

Ernest J. Feleppa,1 S. Kaisar Alam,1 and Cheri X. Deng2

1Riverside Research Institute, Biomedical Engineering Laboratories, 156 William Street, New York, NY 10038-2609, USA
2Case Western Reserve University, Department of Biomedical Engineering, 10900 Euclid Avenue, Cleveland, Ohio 44106-7220, USA

Received 17 November 2003; Accepted 17 November 2003

Copyright © 2002 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Ultrasound has been a popular clinical imaging modality for decades. It is well established as a means of displaying the macroscopic anatomy of soft-tissue structures. While conventional ultrasound methodologies (i.e., B-mode and Doppler methods) are well proven and continue to advance technically on a daily basis, e.g. by extending into higher frequencies and taking advantage of harmonic phenomena in tissues, fundamentally new ultrasound technologies also are emerging and offer exciting promise for making significant improvements in the clinical imaging of disease. These emerging methods include spectrum analysis, elasticity imaging, contrast-agent methods, and advanced flow detection and measurement techniques. Each provides independent information and, used alone, each can provide powerful new imaging capabilities; combined with each other, their capabilities may be even greater in many applications; and all in principle can be used in concert with other imaging modalities to offer the possibility of further improvements in disease detection, evaluation, and monitoring.