Disease Markers

Disease Markers / 2002 / Article

Open Access

Volume 18 |Article ID 482953 | https://doi.org/10.1155/2002/482953

Gregory D. Sides, "QT Interval Prolongation as a Biomarker for Torsades de Pointes and Sudden Death in Drug Development", Disease Markers, vol. 18, Article ID 482953, 6 pages, 2002. https://doi.org/10.1155/2002/482953

QT Interval Prolongation as a Biomarker for Torsades de Pointes and Sudden Death in Drug Development

Received18 Sep 2002
Accepted18 Sep 2002

Abstract

Prolongation of the QT interval on the surface 12-lead electrocardiogram is widely accepted as a biomarker for the potential of a drug to produce torsades de pointes and/or sudden death. Detection of drug-induced prolongation of the QT interval in animals and man is frequently confounded by extrinsic and intrinsic factors that limit the ability to detect a true drug effect. In particular drugs that increase heart rate show an apparent increase in QT interval that confounds assessment of a true drug effect on cardiac ventricular repolarization. The basis for the use of the QT interval as a biomarker will be examined.

Copyright © 2002 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


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