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Disease Markers
Volume 20, Issue 2, Pages 97-102
http://dx.doi.org/10.1155/2004/309391

Development Tracks for Cancer Prevention Markers

Stuart G. Baker,1 Barnett S. Kramer,2 and Philip C. Prorok1

1Biometry Research Group, Division of Cancer Prevention, National Cancer Institute, Bethesda, MD, USA
2Office of Disease Prevention, National Institutes of Health, Bethesda, MD, USA

Received 13 August 2004; Accepted 13 August 2004

Copyright © 2004 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

We provide a general framework for describing various roles for biomarkers in cancer prevention research (early detection, surrogate endpoint, and cohort identification for primary prevention) and the phases in their evaluation.