Disease Markers

Disease Markers / 2004 / Article

Open Access

Volume 20 |Article ID 643086 | https://doi.org/10.1155/2004/643086

Faruk Aşıcıoğlua, Fatma Oguz-Savran, Ugur Ozbek, "Mutation Rate at Commonly Used Forensic STR Loci: Paternity Testing Experience", Disease Markers, vol. 20, Article ID 643086, 3 pages, 2004. https://doi.org/10.1155/2004/643086

Mutation Rate at Commonly Used Forensic STR Loci: Paternity Testing Experience

Received18 Jan 2005
Accepted18 Jan 2005

Abstract

Paternity tests are carried out by the analysis of hypervariable short tandem repeat DNA loci. These microsatellite sequences mutate at a higher rate than that of bulk DNA. The occurrence of germline mutations at STR loci posses problems in interpretation of resulting genetic profiles. We recently analyzed 59–159 parent/child allele transfers at 13 microsatellite loci. We identified 12 mutations in 7 microsatellite loci. No mutations were occurred in other 6 loci. The highest mutation rate was observed with 5 mutations at D8S1179 locus at different alleles. The event was always single repeat related. The mutation rate was between 0 and 1.5 x 10-2 per locus per gamete per generation. The mutation event is very crucial for forensic DNA testing and accumulation of STR mutation data is extremely important for genetic profile interpretation.

Copyright © 2004 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


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