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Disease Markers
Volume 22, Issue 4, Pages 265-269
http://dx.doi.org/10.1155/2006/786720
Regular Article

Expression of Telomerase Reverse Transcriptase in Psoriatic Lesional Skin

Moushira A. Mahmoud,1 Roshdy W. Mohamed,2 Fadia M. Attia,3 Mona A. Atwa,2 and Samir M. Abdel-moneim1

1Department of Biochemistry, Suez Canal University, Ismailia, Egypt
2Department of Dermatology and Andrology, Suez Canal University, Ismailia, Egypt
3Department of Clinical Pathology, Suez Canal University, Ismailia, Egypt

Received 10 November 2006; Accepted 10 November 2006

Copyright © 2006 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Background: Little information is known about telomerase expression in the chronic benign hyperproliferative skin disease, psoriasis. Further studies are still required to investigate its usefulness as a biomarker of this skin disorder. Aim: To investigate the expression of human telomerase reverse transcriptase (hTERT) in psoriatic lesional skin and its relation to disease severity. Methods: The levels of hTERT-mRNA were quantified using real time RT-PCR in lesional versus nonlesional skin specimens from 24 psoriatic patients. Results: The expression of hTERT was detected in 16 psoriatic lesional specimens (66.7%), but in none of the normal skin. There was no relation between hTERT expression level and age of the patient or the duration of the disease. Among hTERT-positive patients, a significant positive correlation was observed between hTERT-mRNA levels and both the Psoriasis Area-and-Severity Index (PASI) and scaling scores (p = 0.012 & p = 0.006, respectively). Conclusion: Telomerase mRNA is detectable in lesional skin of most psoriatic patients and correlates with the severity of the disease and the rate of epidermal proliferation.