Disease Markers

Disease Markers / 2008 / Article
Special Issue

Stem Cells and Disease

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Volume 24 |Article ID 396281 | https://doi.org/10.1155/2008/396281

Sharon R. Pine, Blair Marshall, Lyuba Varticovski, "Lung Cancer Stem Cells", Disease Markers, vol. 24, Article ID 396281, 10 pages, 2008. https://doi.org/10.1155/2008/396281

Lung Cancer Stem Cells

Received21 May 2008
Accepted21 May 2008

Abstract

Lung cancer remains a major cause of cancer-related lethality because of high incidence and recurrence in spite of significant advances in staging and therapies. Recent data indicates that stem cells situated throughout the airways may initiate cancer formation. These putative stem cells maintain protumorigenic characteristics including high proliferative capacity, multipotent differentiation, drug resistance and long lifespan relative to other cells. Stem cell signaling and differentiation pathways are maintained within distinct cancer types, and destabilization of this machinery may participate in maintenance of cancer stem cells. Characterization of lung cancer stem cells is an area of active research and is critical for developing novel therapies. This review summarizes the current knowledge on stem cell signaling pathways and cell markers used to identify the lung cancer stem cells.

Copyright © 2008 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


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