Disease Markers

Disease Markers / 2008 / Article
Special Issue

Optical Spectroscopic Markers of Cancer

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Volume 25 |Article ID 651308 | https://doi.org/10.1155/2008/651308

Shwayta Kukreti, Albert Cerussi, Bruce Tromberg, Enrico Gratton, "Intrinsic Near-Infrared Spectroscopic Markers of Breast Tumors", Disease Markers, vol. 25, Article ID 651308, 10 pages, 2008. https://doi.org/10.1155/2008/651308

Intrinsic Near-Infrared Spectroscopic Markers of Breast Tumors

Received09 Feb 2009
Accepted09 Feb 2009


We have discovered quantitative optical biomarkers unique to cancer by developing a double-differential spectroscopic analysis method for near-infrared (NIR, 650–1000 nm) spectra acquired non-invasively from breast tumors. These biomarkers are characterized by specific NIR absorption bands. The double-differential method removes patient specific variations in molecular composition which are not related to cancer, and reveals these specific cancer biomarkers. Based on the spectral regions of absorption, we identify these biomarkers with lipids that are present in tumors either in different abundance than in the normal breast or new lipid components that are generated by tumor metabolism. Furthermore, the O-H overtone regions (980–1000 nm) show distinct variations in the tumor as compared to the normal breast. To quantify spectral variation in the absorption bands, we constructed the Specific Tumor Component (STC) index. In a pilot study of 12 cancer patients we found 100% sensitivity and 100% specificity for lesion identification. The STC index, combined with other previously described tissue optical indices, further improves the diagnostic power of NIR for breast cancer detection.

Copyright © 2008 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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