Disease Markers

Disease Markers / 2008 / Article

Open Access

Volume 24 |Article ID 679893 | https://doi.org/10.1155/2008/679893

Mario Anders, Mario Sarbia, Carsten Grotzinger, Alexander Meining, Heinz Hofler, Bertram Wiedenmann, Thomas Rosch, "Expression of EpCam and Villin in Barrett’s Esophagus and in Gastric Cardia", Disease Markers, vol. 24, Article ID 679893, 6 pages, 2008. https://doi.org/10.1155/2008/679893

Expression of EpCam and Villin in Barrett’s Esophagus and in Gastric Cardia

Received23 Jul 2008
Accepted23 Jul 2008


In the current study we aimed to clarify the potential of EpCAM and villin as in vivo biomarkers for both Barrett esophagus (BE)-associated neoplasia and BE versus cardiac mucosa. Immunohistochemical staining in BE with various degrees of intraepithelial neoplasia (IN), Barrett carcinoma (BC) and in normal cardiac mucosa (CM) revealed a lack of EpCam and villin in squamous esophageal epithelium. All specimens of IN and BC showed EpCam with varying staining intensities. In 57% of CM samples a weak signal was detected; the remainder displayed strong EpCam expression. Villin was found in 97% of BE specimens and in all those with IN; 37% of BC and 75% of CM specimens were also positive. We conclude that expression of EpCam and villin differs only between squamous epithelium and BE. Determination of these proteins does not allow discrimination between different degrees of neoplasia or between esophageal intestinal metaplasia and cardiac mucosa.

Copyright © 2008 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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