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Disease Markers
Volume 26, Issue 1, Pages 35-39

Oxidative Stress is Increased in Serum from Mexican Patients with Relapsing-Remitting Multiple Sclerosis

Genaro Gabriel Ortiz,1,2 Miguel Ángel Macías-Islas,4 Fermín P. Pacheco-Moisés,5 José A. Cruz-Ramos,1 Silvia Sustersik,1 Elías Alejandro Barba,2 and Adriana Aguayo6

1Laboratorio de Estrés Oxidativo & Patología, División de Neurociencias, Centro de Investigación Biomédica de Occidente (CIBO), Instituto Mexicano del Seguro Social (IMSS), Guadalajara, Jalisco, Mexico
2División de Ciencias de la Salud, Instituto Tecnológico de Estudios Superiores de Monterrey (ITESM) Campus Guadalajara, Zapopan, Jalisco, Mexico
3Departamento de Neurología, Unidad Médica de Alta Especialidad (UMAE)- Hospital de Especialidades, Centro Médico Nacional de Occidente (CMNO), IMSS, Guadalajara, Jalisco, Mexico
4Departamento de Neurosciences, CUCS, Universidad de Guadalajara, Guadalajara, Jalisco, Mexico
5Departamento de Química, Centro Universitario de Ciencias Exactas e Ingenierías, Universidad de Guadalajara, Guadalajara, Jalisco, Mexico
6Fundación Mexicana para la Esclerosis Múltiple A.C. Guadalajara, Jalisco, Mexico

Received 23 February 2009; Accepted 23 February 2009

Copyright © 2009 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Objective: To determine the oxidative stress markers in serum from patients with relapsing-remitting multiple sclerosis. Methods: Blood samples from healthy controls and 22 patients 15 women (7 aged from 20 to 30 and 8 were > 40 years old) and 7 men (5 aged from 20 to 30 and 2 were > 40 years old) fulfilling the McDonald Criteria and classified as having Relapsing-Remitting Multiple Sclerosis accordingly with Lublin were collected for oxidative stress markers quantification. Results: Nitric oxide metabolites (nitrates/nitrites), lipid peroxidation products (malondialdehyde plus 4-hidroxialkenals), and glutathione peroxidase activity were significantly increased in serum of subjects with relapsing-remitting multiple sclerosis in comparison with that of healthy controls. These data support the hypothesis that multiple sclerosis is a component closely linked to oxidative stress.