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Disease Markers
Volume 26, Issue 5-6, Pages 217-225

Markers of Inflammation and Risk of Coronary Heart Disease

Nadeem Sarwar,1,2 Alexander J. Thompson,2 and Emanuele Di Angelantonio2

1Section of Population Health, University of Aberdeen, UK
2Department of Public Health and Primary Care, University of Cambridge, UK

Received 15 September 2009; Accepted 15 September 2009

Copyright © 2009 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Cardiovascular disease is the leading cause of global mortality, with coronary heart disease (CHD) its major manifestation. Although inflammation, the body’s response to noxious stimuli, is implicated in several stages of CHD development, the relevance of circulating levels of markers of inflammation to CHD risk remains uncertain. This review summarizes available epidemiological evidence for four emerging inflammatory markers implicated in CHD (fibrinogen, C-reactive protein, lipoprotein-associated phospholipase A2 and interleukin-6); considers their likely utility in cardiovascular risk prediction; and outlines areas of outstanding uncertainty.